Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856905 | 0.93 | BTK (0.38) | PARP10PARP14KCNH2OPRK1BTK | |
| SCHEMBL19856960 | 0.91 | PLA2G10 (0.38) | KCNH2OPRK1PLA2G10 | |
| SCHEMBL19856969 | 0.87 | BTK (0.37) | PARP10PARP14KCNH2MGLLBTK | |
| SCHEMBL19856981 | 0.86 | SIRT3 (0.38) | — | |
| SCHEMBL19856991 | 0.85 | SLC6A7 (0.37) | PLA2G10DPP4DPP7 | |
| SCHEMBL19856988 | 0.85 | NOD2 (0.41) | PLA2G10 | |
| SCHEMBL19857001 | 0.83 | TRPA1 (0.40) | MGLL | |
| SCHEMBL19856992 | 0.80 | CCR2 (0.34) | MGLLPLA2G10 | |
| SCHEMBL19856952 | 0.79 | ALDH1A1 (0.39) | — | |
| SCHEMBL19856907 | 0.79 | HCRTR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |