Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12017843 | 0.78 | ATM (0.40) | HTR7KCNH3ALDH1A1MAPTHTT | |
| SCHEMBL31313551 | 0.77 | HTR7 (0.38) | HTR7KCNH3ALDH1A1MAPTHTT | |
| SCHEMBL13762197 | 0.75 | HRH3 (0.51) | HRH3RXFP1KCNH3ALDH1A1MEN1 | |
| SCHEMBL21064122 | 0.75 | HRH3 (0.36) | HRH3CYP3A4 | |
| SCHEMBL12015779 | 0.74 | HTR7 (0.45) | HTR7KCNH3ALDH1A1NCF1RIPK2 | |
| SCHEMBL13762190 | 0.74 | MAPT (0.49) | HRH3KCNH3ALDH1A1MEN1MAPT | |
| SCHEMBL12412535 | 0.71 | KCNH3 (0.41) | KCNH3ALDH1A1MEN1MAPTHTT | |
| SCHEMBL22010700 | 0.71 | ALDH1A1 (0.46) | HRH3ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL6086824 | 0.71 | ALPL (0.46) | ALDH1A1RIPK2HCAR3KDM4E | |
| SCHEMBL14005537 | 0.70 | RXFP1 (0.41) | RXFP1BRAFALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136386-B2 | Methods of treating Crohn's disease or ulcerative colitis by administering inhibitors of tumor necrosis factor-like cytokine 1A (TL1A) | PROMETHEUS BIOSCIENCES, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210277477-A1 | METHODS OF TREATING REFRACTORY INFLAMMATORY DISEASE USING TRANSCRIPTOMIC AND GENETIC RISK SIGNATURES | CEDARS-SINAI MEDICAL CENTER | 2021-09-09 | — | — | US | disclosed |
| US-20210101988-A1 | TL1A PATIENT SELECTION METHODS, SYSTEMS, AND DEVICES | CEDARS-SINAI MEDICAL CENTER | 2021-04-08 | — | — | US | disclosed |
| US-20210079473-A1 | METHODS AND SYSTEMS FOR CHARACTERIZING SEVERE CROHN'S DISEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-03-18 | — | — | US | disclosed |
| US-20200362025-A1 | TL1A PATIENT SELECTION METHODS, SYSTEMS, AND DEVICES | CEDARS-SINAI MEDICAL CENTER | 2020-11-19 | — | — | US | disclosed |
| US-20180072703-A1 | PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF RIPK2 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200362025-A1 | TL1A PATIENT SELECTION METHODS, SYSTEMS, AND DEVICES | TLL1, TLN1, TSG101 | HRH3 4185/4885HTR7 3505/4885RXFP1 3861/4885 |
| US-20210101988-A1 | TL1A PATIENT SELECTION METHODS, SYSTEMS, AND DEVICES | TLL1, TLN1, TSG101 | HRH3 4185/4885HTR7 3505/4885RXFP1 3861/4885 |
| US-11136386-B2 | Methods of treating Crohn's disease or ulcerative colitis by administering inhibitors of tumor necrosis factor-like cytokine 1A (TL1A) | LTA, TLL1, TNF | HRH3 3857/4885HTR7 3238/4885RXFP1 1601/4885 |
| US-20180072703-A1 | PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF RIPK2 | RIPK2, RIPK1, RIPK4 | HRH3 870/4885HTR7 2470/4885RXFP1 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.