SCHEMBL19983769

SCHEMBL19983769

CNCc1c[nH]c2cc(Nc3ncccc3C(F)(F)F)ccc12

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 6/20 0.44
GRM4 Q14833 8/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19984015 0.86 GRM4 (0.39) GRM4
SCHEMBL19983828 0.84 LMNA (0.38) GRM4
SCHEMBL19983890 0.84 EGFR (0.43) GRM4
SCHEMBL19984142 0.84 BACE1 (0.39) GRM4
SCHEMBL19983863 0.79 GPR84 (0.38) GRM4
SCHEMBL19983892 0.78 PTGS2 (0.46) GRM4
SCHEMBL19983845 0.77 TBXAS1 (0.44) TRPV1
SCHEMBL19983904 0.77 GRM4 (0.45) GRM4
SCHEMBL8111778 0.76 HTR1D (0.50)
SCHEMBL19983989 0.76 GPR84 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed