Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Menadione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.72 |
| ▸ | RAF1 known ✓ | P04049 | 1/20 | 0.47 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | CDC25A | P30304 | 4/20 | 0.72 |
| ▸ | CDC25B | P30305 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.72 |
| ▸ | IDO1 | P14902 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.72 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menadione SCHEMBL30514399 | 1.00 | ALDH1A1 (0.72) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL10981249 | 0.93 | ALDH1A1 (0.78) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL433363 | 0.91 | ALDH1A1 (0.81) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL1846014 | 0.89 | ALDH1A1 (0.78) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL6675827 | 0.89 | ALDH1A1 (0.78) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL29351164 | 0.85 | MAPT (1.00) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL25970 | 0.85 | MAPT (1.00) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL1364028 | 0.85 | MAPT (1.00) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL19356853 | 0.85 | MAPT (1.00) | ALDH1A1MAPTCDC25ACDC25BHPGD | |
| Menadione SCHEMBL10610956 | 0.84 | CDC25A (0.55) | ALDH1A1MAPTCDC25ACDC25BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507555-B2 | Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone | SUMMA HEALTH SYSTEM (US) | 2013-08-13 | — | — | US | claimed |
| US-5116406-A | Choline chloride and vitamin k | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1992-05-26 | — | — | US | claimed |
| CN-115461096-B | Polymer encapsulated drug particles | 吉益医疗公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-116998638-A | Copper-zinc additive feed for promoting growth health of pelteobagrus fulvidraco and preparation method thereof | 华中农业大学 | 2023-11-07 | — | — | CN | disclosed |
| CN-113185433-B | Preparation method of menadione sodium bisulfate | 新发药业有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-110343666-B | Feed supplement culture medium for CHO cell culture and preparation method and application thereof | 通化东宝药业股份有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-113185431-B | Green preparation method of menadione sodium bisulfite | 新发药业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-113185433-A | Preparation method of menadione sodium bisulfite | 新发药业有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-113185431-A | Green preparation method of menadione sodium bisulfite | 新发药业有限公司 | 2021-07-30 | — | — | CN | disclosed |
| US-11052046-B2 | Method for preparing micro-particles by double emulsion technique | NANOMI B.V. (NL) | 2021-07-06 | — | — | US | disclosed |
| US-20210015752-A1 | METHODS FOR PRODUCING PARTICLES OF AN ACTIVE INGREDIENT | SAVIOR LIFETEC CORPORATION (TW) | 2021-01-21 | — | — | US | disclosed |
| EP-0065513-B1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1985-09-18 | — | — | EP | disclosed |
| EP-0065513-B1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1985-09-18 | — | — | EP | disclosed |
| EP-0117321-A2 | Foodstuffs, including chewing gum with anti-caries activity, and processes for preparing them | TABAGH AG (CH) | 1984-09-05 | — | — | EP | disclosed |
| EP-0065513-A4 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1983-03-29 | — | — | EP | disclosed |
| EP-0065513-A4 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1983-03-29 | — | — | EP | disclosed |
| EP-0065513-A1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1982-12-01 | — | — | EP | disclosed |
| EP-0065513-A1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1982-12-01 | — | — | EP | disclosed |
| WO-1982001821-A1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | KOVACS ANDRAS | 1982-06-10 | — | — | WO | disclosed |
| WO-1982001821-A1 | ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF | KOVACS ANDRAS | 1982-06-10 | — | — | WO | disclosed |