Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547654 | 0.83 | MEN1 (0.41) | CYP3A4ALDH1A1CYP2C19LMNACA2 | |
| SCHEMBL22454811 | 0.83 | ALDH1A1 (0.35) | CYP3A4ALDH1A1CYP2C19ACE2MEN1 | |
| SCHEMBL17298377 | 0.80 | KCNJ11 (0.50) | ALDH1A1LMNAHPGDMEN1MAPT | |
| SCHEMBL24910099 | 0.78 | P2RX7 (0.37) | GABRA1GABRB2KCNJ11TRPA1 | |
| SCHEMBL8781825 | 0.78 | GABRA1 (0.48) | CYP3A4GABRA1GABRB2GABRG2GABRB3 | |
| SCHEMBL30876294 | 0.78 | GABRA1 (0.48) | CYP3A4GABRA1GABRB2GABRG2GABRB3 | |
| SCHEMBL16849211 | 0.78 | HSD11B1 (0.33) | CYP3A4ALDH1A1CYP2C19GABRA1GABRB2 | |
| SCHEMBL3369244 | 0.75 | CYP3A4 (0.61) | CYP3A4ALDH1A1CYP2C19GABRA1GABRB2 | |
| SCHEMBL548252 | 0.74 | CA2 (0.46) | CYP3A4ALDH1A1CYP2C19GABRA1GABRB2 | |
| SCHEMBL16852471 | 0.74 | CYP1A2 (0.56) | CYP3A4ALDH1A1CYP2C19GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | PHENEX PHARMACEUTICALS AG (DE) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | RORA, RORB, RORC | CYP3A4 836/4885ALDH1A1 671/4885CYP2C19 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.