SCHEMBL21150757

SCHEMBL21150757

O=C(O)CCS(=O)(=O)N1CCC(N2CC(=O)N(c3ccccc3)C2=O)CC1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 2/20 0.38
ENPP2 Q13822 1/20 0.38
F2 P00734 2/20 0.37
F10 P00742 2/20 0.37
PRSS1 P07477 2/20 0.37
GRM4 Q14833 1/20 0.37
MEN1 O00255 1/20 0.37
CNR1 P21554 2/20 0.35
KDM4E B2RXH2 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21150756 0.86 GPR119 (0.37) ALDH1A1MAPTKMT2AF2F10
SCHEMBL24974367 0.85 SMN1; SMN2 (0.40) KMT2AMEN1KDM4ECYP1A2CYP2C9
SCHEMBL24974751 0.79 ALDH1A1 (0.38) ALDH1A1MAPTKMT2AF2F10
SCHEMBL24974651 0.76 MT-CO2 (0.45) ALDH1A1MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL24974603 0.75 NAMPT (0.43) ALDH1A1MAPTKMT2AGRM4MEN1
SCHEMBL21150805 0.74 YAP1 (0.46) ALDH1A1MAPTKMT2AENPP2F2
SCHEMBL29590229 0.72 GRM4 (0.48) ALDH1A1MAPTKMT2AENPP2GRM4
SCHEMBL21150753 0.70 GRM4 (0.46) ALDH1A1KMT2AENPP2GRM4MEN1
SCHEMBL21150798 0.70 GPR119 (0.57) MAPTKDM4E
SCHEMBL21150773 0.69 ITGB3 (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 US disclosed
WO-2019136442-A1 CD16A BINDING AGENTS AND USES THEREOF KLEO PHARMACEUTICALS, INC. (US) 2019-07-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B ALDH1A1 1203/4885MAPT 4695/4885KMT2A 499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.