Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | JUN | P05412 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084348 | 0.82 | MMP2 (0.73) | MMP2MMP9MMP13MAPTCYP1A2 | |
| SCHEMBL18427611 | 0.81 | RAB9A (0.63) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL2184876 | 0.80 | KDM4E (0.67) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL16585159 | 0.80 | KDM4E (0.67) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL2184878 | 0.80 | KDM4E (0.67) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL13100957 | 0.80 | RAB9A (0.67) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL3226180 | 0.79 | LMNA (0.56) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL3226170 | 0.79 | LMNA (0.56) | MAPTRAB9ANPC1KDM4EJUN | |
| SCHEMBL2123091 | 0.77 | MMP2 (0.70) | MMP2MMP9MMP13MMP8 | |
| SCHEMBL24150008 | 0.75 | NPC1 (0.59) | MAPTRAB9ANPC1KDM4EJUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-10-31 | — | — | US | disclosed |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-24 | — | — | US | disclosed |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-24 | — | — | US | disclosed |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-03-21 | — | — | US | disclosed |
| US-20210322346-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-10-21 | — | — | US | disclosed |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-25 | — | — | US | disclosed |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-25 | — | — | US | disclosed |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2020-06-02 | — | — | US | disclosed |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2020-06-02 | — | — | US | disclosed |
| EP-3206488-B1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | UNIV NEW YORK STATE RES FOUND (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9187406-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150150834-A1 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES | CHEM-MASTER INTERNATIONAL, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150150834-A1 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES | CHEM-MASTER INTERNATIONAL, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-03-12 | — | — | US | disclosed |
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-03-12 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| WO-2010132815-A9 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010132815-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073021-A1 | CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR | ANTXR2, APAF1, LITAF | MMP2 224/4885MMP9 1104/4885MMP13 928/4885 |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | NFRKB, NFKBIA, NFKB1 | MMP2 32/4885MMP9 17/4885MMP13 12/4885 |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20150150834-A1 | POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES | BAZ2B, CEBPZ, BAZ2A | MMP2 2518/4885MMP9 1634/4885MMP13 886/4885 |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | MMP2 19/4885MMP9 12/4885MMP13 11/4885 |
| US-20210322346-A1 | CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS | ALOX15B, ALOX15, ALOX12 | MMP2 691/4885MMP9 1330/4885MMP13 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.