Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CES2 | O00748 | 3/20 | 0.55 |
| ▸ | CES1 | P23141 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460667 | 0.77 | ALDH1A1 (0.52) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL499513 | 0.74 | ALDH1A1 (0.50) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL409672 | 0.74 | ALDH1A1 (0.65) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL5179861 | 0.74 | ALDH1A1 (0.50) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL1411939 | 0.74 | ALDH1A1 (0.55) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| 4-Methylbenzoic Acid SCHEMBL7261856 | 0.72 | ALDH1A1 (0.94) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL16326612 | 0.72 | ALDH1A1 (0.62) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL547749 | 0.72 | ALDH1A1 (0.48) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL1893113 | 0.72 | ALDH1A1 (0.62) | ALDH1A1CES2CES1LMNASMN1; SMN2 | |
| SCHEMBL202776 | 0.72 | SMN1; SMN2 (0.56) | ALDH1A1CES2CES1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | claimed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | claimed |
| EP-2228376-B1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | KITASATO INST (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-8519128-B2 | Pyripyropene derivatives having an ACAT2-inhibiting activity | THE KITASATO INSTITUTE (JP) | 2013-08-27 | — | — | US | disclosed |
| US-8318932-B2 | Process for producing 4-aminoquinazoline compound | UBE INDUSTRIES, LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | disclosed |
| US-7858807-B2 | Method for producing 1-substituted-5-acylimidazole compound | UBE INDUSTRIES, LTD. (JP) | 2010-12-28 | — | — | US | disclosed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | disclosed |
| US-20090306399-A1 | METHOD FOR PRODUCING 1-SUBSTITUTED-5-ACYLIMIDAZOLE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| US-7619084-B2 | Reacting an acrylonitrile, ammonia and alkyl orthoformate in an ammonia-isopropyl alcoholsolution under stirring at 145 degrees C. for 12 hours; nonteratogenicity, nontoxic; simplification; industrial scale; chemical intermediates; drugs; agricultural chemicals | UBE INDUSTRIES, LTD. (JP) | 2009-11-17 | — | — | US | disclosed |
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| US-20090137822-A1 | Process for preparing 3-substituted thiophene | UBE INDUSTRIES, LTD. (JP) | 2009-05-28 | — | — | US | disclosed |
| US-20080306287-A1 | Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound | UBE INDUSTRIES, LTD. (JP) | 2008-12-11 | — | — | US | disclosed |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2008-07-24 | — | — | US | disclosed |
| US-20080045712-A1 | Process for Preparing 4-Aminopyrimidine Compound | UBE INDUSTRIES, LTD. (JP) | 2008-02-21 | — | — | US | disclosed |
| EP-1057808-B1 | Sulfur-containing unsaturated carboxylate compound and its use | MITSUI CHEMICALS INC (JP) | 2007-03-14 | — | — | EP | disclosed |
| US-6458908-B1 | A PROCESS FOR PREPARING A SULFUR-CONTAINING UNSATURATED CARBOXYLATE COMPOUND AS CLAIMED IN CLAIM 1 COMPRISING REACTING A SULFUR-CONTAINING DERIVATIVE FOR OPTICAL POLYMERS | MITSUI CHEMICALS, INC. (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-1057808-A2 | Sulfur-containing unsaturated carboxylate compound and its use | Mitsui Chemicals, Inc. (JP) | 2000-12-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | ALDH1A1 1242/4885CES2 1165/4885CES1 2064/4885 |
| US-20080306287-A1 | Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound | ADH1A, ADH1C, HPD | ALDH1A1 29/4885CES2 97/4885CES1 103/4885 |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | ACAT2, ACAT1, AGPAT2 | ALDH1A1 1202/4885CES2 953/4885CES1 144/4885 |
| US-20080045712-A1 | Process for Preparing 4-Aminopyrimidine Compound | ALKBH1, CBR1, CYP4B1 | ALDH1A1 279/4885CES2 2092/4885CES1 2289/4885 |
| US-20090306399-A1 | METHOD FOR PRODUCING 1-SUBSTITUTED-5-ACYLIMIDAZOLE COMPOUND | AADAC, KAT5, HDAC5 | ALDH1A1 659/4885CES2 1850/4885CES1 1420/4885 |
| US-20090137822-A1 | Process for preparing 3-substituted thiophene | TMT1A, CTH, CBR1 | ALDH1A1 37/4885CES2 290/4885CES1 320/4885 |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | ALDH1A1 1242/4885CES2 1165/4885CES1 2064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.