SCHEMBL2189933

SCHEMBL2189933

O=C(Cl)c1cccc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46
ALDH1A1 P00352 1/20 0.44
ALOX15 P16050 1/20 0.44
CTSS P25774 3/20 0.40
TAS2R14 Q9NYV8 2/20 0.40
PTGS1 P23219 1/20 0.39
KCNK3 O14649 1/20 0.39
KCNK9 Q9NPC2 1/20 0.39
FABP4 P15090 1/20 0.39
CTSK P43235 2/20 0.38
CTNNB1 P35222 2/20 0.38
WNT3A P56704 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NOTUM Q6P988 1/20 0.37
CNR2 P34972 1/20 0.37
NFKB1 P19838 1/20 0.37
P2RX7 Q99572 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23041398 0.84 LMNA (0.48) LMNAGAAALDH1A1CTSSTAS2R14
SCHEMBL7399514 0.82 LMNA (0.47) LMNAGAAALDH1A1CTSSTAS2R14
SCHEMBL1195140 0.82 TAS2R14 (0.51) LMNAGAAALDH1A1ALOX15TAS2R14
SCHEMBL24201 0.82 LMNA (0.60) LMNAGAAALDH1A1ALOX15TAS2R14
SCHEMBL20268801 0.81 ALDH1A1 (0.47) LMNAALDH1A1ALOX15SMN1; SMN2NOTUM
SCHEMBL937001 0.81 ALDH1A1 (0.59) LMNAGAAALDH1A1ALOX15CTSS
SCHEMBL29789811 0.81 ALDH1A1 (0.59) LMNAGAAALDH1A1ALOX15CTSS
SCHEMBL283643 0.81 KAT6A (0.49) LMNAGAAALDH1A1ALOX15CTSS
SCHEMBL3108190 0.81 LMNA (0.46) LMNAGAATAS2R14PTGS1KCNK3
SCHEMBL634076 0.81 PARP1 (0.47) LMNAGAAALDH1A1CTSSTAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12517285-B2 Multilayer optical films comprising at least one fluorinated (co)polymer layer made using a fluorinated photoinitiator, and methods of making and using the same 3M INNOVATIVE PROPERTIES COMPANY (US) 2026-01-06 US disclosed
US-12384807-B2 Fluorinated photoinitiators and fluorinated (co)polymer layers made using the same 3M INNOVATIVE PROPERTIES COMPANY (US) 2025-08-12 US disclosed
US-20240067621-A1 POLYFLUORINATED CANNABINOID AND CANNABINOID-LIKE COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF WEAVER JIMMIE D (US) 2024-02-29 US disclosed
US-20240060068-A1 POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS EISAI R&D MANAGEMENT CO., LTD. (JP) 2024-02-22 US disclosed
EP-4305681-A1 NEW CERIUM (IV) COMPLEXES AND THEIR USE IN ORGANIC ELECTRONICS CREDOXYS GmbH (DE) 2024-01-17 EP disclosed
EP-4298096-A1 POLYFLUORINATED DICYCLIC COMPOUNDS AND METHODS OF SYNTHESIS THEREOF The Board of Regents for the Oklahoma Agricultural And Mechanical Colleges (US) 2024-01-03 EP disclosed
WO-2023248871-A1 HETEROARYL COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2023-12-28 WO disclosed
CN-117120456-A Poly-morpholino oligonucleotide gap body 卫材R&D管理有限公司 2023-11-24 CN disclosed
CN-116964026-A Novel cerium (IV) complexes and their use in electronics 克雷多西斯有限公司 2023-10-27 CN disclosed
EP-4259798-A1 POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS Eisai R&D Management Co., Ltd. (JP) 2023-10-18 EP disclosed
WO-1997030989-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed
EP-0783490-A1 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE COMPOUNDS Novartis AG (CH) 1997-07-16 EP disclosed
WO-1997016440-A1 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-SUBSTITUTED PIPERAZINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1997-05-09 WO disclosed
EP-0739892-A2 Chromone derivatives CIBA-GEIGY AG (CH) 1996-10-30 EP disclosed
WO-1996029328-A1 MORPHOLINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME LIMITED (GB) 1996-09-26 WO disclosed
EP-0418175-B1 Isoxazoles herbicides RHONE POULENC AGRICULTURE (GB) 1996-07-17 EP disclosed
EP-0707006-A1 Aroyl-piperidine derivatives CIBA-GEIGY AG (CH) 1996-04-17 EP disclosed
WO-1996010562-A1 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE COMPOUNDS NOVARTIS AG (CH) 1996-04-11 WO disclosed
WO-1995033458-A1 ANTI-INFLAMMATORY COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1995-12-14 WO disclosed
EP-0418175-A2 Isoxazoles herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1991-03-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067621-A1 POLYFLUORINATED CANNABINOID AND CANNABINOID-LIKE COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF CNR2, CNR1, FAAH LMNA 2128/4885GAA 2419/4885ALDH1A1 4183/4885
US-20240060068-A1 POLY-MORPHOLINO OLIGONUCLEOTIDE GAPMERS RNMT, GAP43, MCTS1 LMNA 1584/4885GAA 1510/4885ALDH1A1 4689/4885
US-12384807-B2 Fluorinated photoinitiators and fluorinated (co)polymer layers made using the same ESD, FMNL1, FES LMNA 2516/4885GAA 4472/4885ALDH1A1 2781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.