Sugi Predict

Sugi Predict / Compounds / SCHEMBL2190730

SCHEMBL2190730

SCHEMBL2190730

CC(C)(C)OC(=O)NC(C)(C)C(N)=O

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.40
▸ MAOB P27338 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.37
▸ CA12 O43570 3/20 0.37
▸ CA14 Q9ULX7 3/20 0.37
▸ DGAT1 O75907 1/20 0.37
▸ CA1 P00915 3/20 0.36
▸ CA2 P00918 3/20 0.36
▸ CA7 P43166 2/20 0.36
▸ MEN1 O00255 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ APLNR P35414 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14152601 0.84 KDM4E (0.37) MAOAMAOBTDP1CA12CA14
SCHEMBL14152603 0.84 KDM4E (0.37) MAOAMAOBTDP1CA12CA14
SCHEMBL14152602 0.84 KDM4E (0.37) MAOAMAOBTDP1CA12CA14
SCHEMBL9451891 0.83 GAA (0.38) MAOAMAOBTDP1CA12CA14
SCHEMBL18636583 0.83 MAOA (0.38) MAOAMAOBTDP1CA12CA14
SCHEMBL14276786 0.81 TDP1 (0.39) TDP1CA12CA14DGAT1CA1
SCHEMBL4783072 0.81 ALDH1A1 (0.30) DGAT1
SCHEMBL76832 0.79 KDM4C (0.41) TDP1CA12CA14DGAT1CA1
SCHEMBL27680256 0.78 TDP1 (0.35) MAOAMAOBTDP1CA12CA14
Acetic Acid SCHEMBL31381638 0.78 CTSK (0.35) MAOAMAOBTDP1CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11655260-B2 Heterocyclic compounds as arginase inhibitors GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) 2023-05-23 — — US disclosed
US-20220251116-A1 ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) 2022-08-11 — — US disclosed
US-11046729-B2 Dipeptide analogs as TGF-beta inhibitors SOUTHERN RESEARCH INSTITUTE (US) 2021-06-29 — — US disclosed
WO-2020160707-A1 ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) 2020-08-13 — — WO disclosed
US-20190127420-A1 DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS UAB RESEARCH FOUNDATION 2019-05-02 — — US disclosed
EP-3072886-B1 PYRIDIN-2-AMIDES USEFUL AS CB2 AGONISTS HOFFMANN LA ROCHE (CH) 2018-04-18 — — EP disclosed
EP-3072886-B1 PYRIDIN-2-AMIDES USEFUL AS CB2 AGONISTS HOFFMANN LA ROCHE (CH) 2018-04-18 — — EP disclosed
EP-2841435-B1 PYRROLOPYRIDINONE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC (JP) 2017-09-06 — — EP disclosed
US-20170073341-A1 Benzene Sulfonamide Thiazole and Oxazole Compounds NOVARTIS AG (CH) 2017-03-16 — — US disclosed
EP-3106462-A1 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS Novartis AG (CH) 2016-12-21 — — EP disclosed
US-20070293490-A1 Quinazoline Derivatives ASTRAZENECA AB (SE) 2007-12-20 — — US disclosed
EP-1153034-B1 GROWTH HORMONE SECRETAGOGUES LILLY CO ELI (US) 2007-10-17 — — EP disclosed
EP-1713781-A1 QUINAZOLINE DERIVATIVES AstraZeneca AB (SE) 2006-10-25 — — EP disclosed
WO-2005075439-A1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2005-08-18 — — WO disclosed
EP-0765879-B1 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests SANKYO CO (JP) 2001-02-14 — — EP disclosed
WO-1999008697-A1 TREATMENT OF CONGESTIVE HEART FAILURE WITH GROWTH HORMONE SECRETAGOGUES ELI LILLY AND COMPANY (US) 1999-02-25 — — WO disclosed
US-5861429-A MITICIDES AND ANTHELMINTICS SANKYO COMPANY, LIMITED (JP) 1999-01-19 — — US disclosed
WO-1998016527-A1 BENZOXEPINE DERIVATIVES WHICH PROMOTE RELEASE OF GROWTH HORMONE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-04-23 — — WO disclosed
EP-0765879-A1 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests SANKYO COMPANY LIMITED (JP) 1997-04-02 — — EP disclosed
WO-1994013696-A1 SPIRO PIPERIDINES AND HOMOLOGS WHICH PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11655260-B2 Heterocyclic compounds as arginase inhibitors ARG1, ARG2, PRMT1 MAOA 169/4885MAOB 162/4885TDP1 494/4885
US-20220251116-A1 ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS ARG1, ARG2, PADI6 MAOA 242/4885MAOB 85/4885TDP1 493/4885
US-20070293490-A1 Quinazoline Derivatives CCNA1, CCND3, CCND2 MAOA 642/4885MAOB 1269/4885TDP1 659/4885
US-20170073341-A1 Benzene Sulfonamide Thiazole and Oxazole Compounds STS, TST, TPST2 MAOA 3141/4885MAOB 3111/4885TDP1 3511/4885
US-20190127420-A1 DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS TGFB1, TGFB2, SMAD3 MAOA 4709/4885MAOB 4541/4885TDP1 1011/4885
US-11046729-B2 Dipeptide analogs as TGF-beta inhibitors TGFB1, TGFB2, SMAD3 MAOA 4709/4885MAOB 4541/4885TDP1 1011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.