SCHEMBL219188

SCHEMBL219188

CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1C[C@@H](O)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 1.00
CHRM1 P11229 1/20 1.00
CHRM3 P20309 1/20 1.00
PREP P48147 4/20 0.52
HSD11B1 P28845 2/20 0.45
LMNA P02545 1/20 0.42
CYP2C9 P11712 1/20 0.42
GPR119 Q8TDV5 3/20 0.40
NR1H2 P55055 1/20 0.39
HPGD P15428 1/20 0.38
USP2 O75604 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KAT2B Q92831 1/20 0.37
RECQL P46063 1/20 0.36
EPHX1 P07099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6761192 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL10106331 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL10106427 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL1023170 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL641026 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL19082743 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL219189 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL22433392 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL20636193 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1
SCHEMBL6157512 1.00 CHRM2 (1.00) CHRM2CHRM1CHRM3PREPHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630562-B2 Piperidylurea compounds and methods of use thereof ARCUS BIOSCIENCES, INC. (US) 2026-05-19 US disclosed
US-20260042777-A1 PIPERIDYLUREA COMPOUNDS AND METHODS OF USE THEREOF ARCUS BIOSCIENCES, INC. (US) 2026-02-12 US disclosed
US-20250115591-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2025-04-10 US disclosed
EP-4519259-A1 TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-12 EP disclosed
US-20240400584-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2024-12-05 US disclosed
US-20240238423-A9 TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS Treeline Biosciences, Inc. 2024-07-18 US disclosed
US-11981667-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2024-05-14 US disclosed
US-20240116912-A1 COMPOUNDS AND METHODS FOR MODULATING FXR TERNS PHARMACEUTICALS, INC. 2024-04-11 US disclosed
US-20230390404-A1 TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS TREELINE BIOSCIENCES INC (US) 2023-12-07 US disclosed
US-20230365526-A1 PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING REMIX THERAPEUTICS INC (US) 2023-11-16 US disclosed
US-20080188484-A1 INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES HOFFMANN-LA ROCHE, INC. 2008-08-07 US disclosed
EP-1948653-A1 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS NeuroSearch A/S (DK) 2008-07-30 EP disclosed
US-20070213359-A1 BICYCLIC-NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF ACADIA PHARMACEUTICALS INC. (US) 2007-09-13 US disclosed
US-20070213359-A1 BICYCLIC-NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF ACADIA PHARMACEUTICALS INC. (US) 2007-09-13 US disclosed
US-20070185156-A1 8-Azabicyclo[3.2.1]octane derivatives N.V. ORGANON (NL) 2007-08-09 US disclosed
WO-2007054531-A1 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS NEUROSEARCH A/S (DK) 2007-05-18 WO disclosed
EP-0937069-B1 PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS SCHERING CORP (US) 2006-05-03 EP disclosed
EP-0975631-B1 5-ARYL-3-(8-AZABICYCLO[3.2.1]OCT-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AS 5-HT4 RECEPTOR LIGANDS SANOFI SYNTHELABO (FR) 2001-10-04 EP disclosed
US-6051575-A RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIINFLAMMATORY AGENTS SCHERING CORPORATION (US) 2000-04-18 US disclosed
US-5968929-A USEFUL IN THE TREATMENT OF CHRONIC AIRWAY DISEASES SUCH AS ASTHMA SCHERING CORPORATION (US) 1999-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240400584-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 CHRM2 4750/4885CHRM1 4495/4885CHRM3 4238/4885
US-20070213359-A1 BICYCLIC-NITROGEN COMPOUNDS AS MODULATORS OF GHRELIN RECEPTOR AND USES THEREOF GIPR, GHSR, GHRHR CHRM2 1113/4885CHRM1 1153/4885CHRM3 1015/4885
US-20230365526-A1 PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING SNRPA, RBM17, SNRPB2 CHRM2 4760/4885CHRM1 4390/4885CHRM3 4461/4885
US-12630562-B2 Piperidylurea compounds and methods of use thereof CLIC1, HCCS, CNR1 CHRM2 172/4885CHRM1 143/4885CHRM3 268/4885
US-20080188484-A1 INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES HRH4, HRH3, HRH2 CHRM2 35/4885CHRM1 20/4885CHRM3 44/4885
US-11981667-B2 Sulfonamide carboxamide compounds NLRP3, NOD1, PYCARD CHRM2 1267/4885CHRM1 1033/4885CHRM3 1343/4885
US-20250115591-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 CHRM2 1374/4885CHRM1 1202/4885CHRM3 1494/4885
US-20240238423-A9 TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS BCL2A1, BCL2L1, BCL3 CHRM2 4819/4885CHRM1 4745/4885CHRM3 4860/4885
US-20240116912-A1 COMPOUNDS AND METHODS FOR MODULATING FXR NR1H4, FXR1, FXR2 CHRM2 2385/4885CHRM1 2509/4885CHRM3 469/4885
US-20230390404-A1 TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS BCL2A1, BCL2L1, BCL3 CHRM2 4819/4885CHRM1 4745/4885CHRM3 4860/4885
US-20260042777-A1 PIPERIDYLUREA COMPOUNDS AND METHODS OF USE THEREOF CBR1, CLIC1, RER1 CHRM2 185/4885CHRM1 149/4885CHRM3 217/4885
US-20070185156-A1 8-Azabicyclo[3.2.1]octane derivatives SLC22A8, SLCO1B3, SLCO1B1 CHRM2 1718/4885CHRM1 1961/4885CHRM3 1579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.