Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093938 | 0.92 | HTR3E (0.50) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL29998630 | 0.83 | HTR3E (0.70) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL870704 | 0.83 | HTR3E (0.70) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL24103508 | 0.78 | SIGMAR1 (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1822749 | 0.78 | HTR3E (0.64) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL2835955 | 0.77 | ADRB1 (0.57) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL662317 | 0.77 | MAPT (0.52) | MEN1KMT2ADRD4ALDH1A1GAA | |
| SCHEMBL3183333 | 0.77 | AKR1C3 (0.44) | MEN1KMT2AAKR1C3ALDH1A1GAA | |
| SCHEMBL7513534 | 0.77 | LTA4H (0.47) | ADRB1MEN1KMT2ALTA4HDRD4 | |
| SCHEMBL216663 | 0.77 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1GAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117986271-A | Cell cycle regulator, and pharmaceutical preparation and application thereof | 贵州大学 | 2024-05-07 | — | — | CN | claimed |
| CN-110669058-A | Tricyclic quinolone carboxylic acid and preparation method thereof | 江西农业大学 | 2020-01-10 | — | — | CN | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2006271-A9 | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2009-07-29 | — | — | EP | claimed |
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | claimed |
| US-20090054401-A1 | Substituted bicyclic derivatives and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-26 | — | — | US | claimed |
| EP-2006271-A2 | SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2008-12-24 | — | — | EP | claimed |
| US-20080280906-A1 | Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | US | claimed |
| EP-1912974-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | claimed |
| US-20070299105-A1 | 2-Cyanopropanoic Acid Amide and Ester Derivatives and Methods of Their Use | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| EP-0174242-B1 | 1-(AMINO-PHENYL)-2-AMINO PROPANON DERIVATIVES, THEIR USE IN THERAPY AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-01-13 | — | — | EP | claimed |
| EP-0138714-B1 | 1-(ACETYLAMINOPHENYL)-2-AMINO-PROPANONE DERIVATIVES, THEIR THERAPEUTICAL USE AND PROCESS FOR THEIR PREPARATION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-05-20 | — | — | EP | claimed |
| EP-0174242-A2 | 1-(Amino-phenyl)-2-amino propanon derivatives, their use in therapy and process for their preparation | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-03-12 | — | — | EP | claimed |
| US-4556656-A | HYPOTENSIVE, ANTIPSYCHOTIC, DIABETIC, AND ANALGESIC AGENTS | THE UPJOHN COMPANY (US) | 1985-12-03 | — | — | US | claimed |
| EP-0138714-A2 | 1-(Acetylaminophenyl)-2-amino-propanone derivatives, their therapeutical use and process for their preparation | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1985-04-24 | — | — | EP | claimed |
| US-4421927-A | SKIN DISORDERS | SOCIETE DE RECHERCHES INDUSTRIELLES (S.O.R.I.) (FR) | 1983-12-20 | — | — | US | claimed |
| EP-0051514-B1 | CINNAMOYL-CINNAMIC ACID DERIVATIVE, ITS PREPARATION AND ITS USE AS A THERAPEUTIC AGENT | SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: (FR) | 1983-11-23 | — | — | EP | claimed |
| US-4390697-A | Process for the preparation of triazoloquinazolinones | ROUSSEL UCLAF (FR) | 1983-06-28 | — | — | US | claimed |
| US-4350695-A | Antihistaminic and bronchospasmolytic triazoloquinazolinones | ROUSSEL UCLAF (FR) | 1982-09-21 | — | — | US | claimed |
| US-3959281-A | CORONARY DILATORS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054401-A1 | Substituted bicyclic derivatives and use thereof | LTB4R2, LTC4S, LTB4R | HTR3E 804/4885HTR3B 835/4885ADRB1 136/4885 |
| US-20070299105-A1 | 2-Cyanopropanoic Acid Amide and Ester Derivatives and Methods of Their Use | HCAR2, PCCA, MCCC2 | HTR3E 4713/4885HTR3B 4307/4885ADRB1 1348/4885 |
| US-20080280906-A1 | Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders | CCNI, MKI67, TYMP | HTR3E 4136/4885HTR3B 3565/4885ADRB1 4294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.