Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438142 | 0.79 | ADRB1 (0.59) | ADRB1HTR7HTR3AHTR1ACYP1A2 | |
| SCHEMBL2414713 | 0.79 | HTR1A (0.39) | ADRB1HTR7HTR3AHTR1AALDH1A1 | |
| SCHEMBL3483188 | 0.78 | DRD2 (0.61) | ADRB1HTR7HTR3AHTR1ALMNA | |
| SCHEMBL8357275 | 0.78 | EPHX2 (0.44) | ADRB1HTR3AHTR1ACYP1A2CYP3A4 | |
| SCHEMBL3951003 | 0.74 | SLC6A2 (0.43) | ADRB1HTR7HTR3AHTR1ALMNA | |
| SCHEMBL7524539 | 0.74 | ALDH1A1 (0.48) | ADRB1HTR3AHTR1ACYP3A4CYP2D6 | |
| SCHEMBL4896 | 0.73 | ADRB1 (1.00) | ADRB1HTR7HTR3AHTR1ACYP1A2 | |
| SCHEMBL29432760 | 0.73 | ADRB1 (1.00) | ADRB1HTR7HTR3AHTR1ACYP1A2 | |
| SCHEMBL2209183 | 0.73 | ADRB1 (1.00) | ADRB1HTR7HTR3AHTR1ACYP1A2 | |
| SCHEMBL739058 | 0.73 | SIGMAR1 (0.52) | ADRB1HTR7HTR3AHTR1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550093-B2 | Third generation taxoids and methods of using same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-02-04 | — | — | US | disclosed |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2018-07-12 | — | — | US | disclosed |
| US-7981926-B2 | Fluorotaxoids | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090118355-A1 | Fluorotaxoids | RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2009-05-07 | — | — | US | disclosed |
| EP-2016065-A2 | 1-(BENZO[D][1,3]DIOXOL-5-YL)-N-(PHENYL)CYCLOPROPANE-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS FOR THE TREATMENT OF CYSTIC FIBROSIS | Vertex Pharmaceuticals Incorporated (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007087066-A2 | 1-(BENZO [D] [1,3] DI0X0L-5-YL) -N- (PHENYL) CYCLOPROPANE- CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS FOR THE TREATMENT OF CYSTIC FIBROSIS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118355-A1 | Fluorotaxoids | FAU, ARF5, ARFGEF1 | ADRB1 3204/4885HTR7 3804/4885HTR3A 1590/4885 |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | CBR3, TUBB3, CBX3 | ADRB1 1355/4885HTR7 2722/4885HTR3A 365/4885 |
| US-10550093-B2 | Third generation taxoids and methods of using same | CBR3, TUBB3, CBX3 | ADRB1 1355/4885HTR7 2722/4885HTR3A 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.