SCHEMBL22324022

SCHEMBL22324022

COc1cc(-n2nccn2)ccc1[N+]#N

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HCRTR1 O43613 4/20 0.36
▸ HCRTR2 O43614 4/20 0.36
▸ G6PD P11413 1/20 0.34
▸ TLR9 Q9NR96 1/20 0.34
▸ BRD9 Q9H8M2 2/20 0.34
▸ MEN1 O00255 2/20 0.31
▸ KMT2A Q03164 2/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ NPC1 O15118 2/20 0.31
▸ RAB9A P51151 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ NOTUM Q6P988 1/20 0.30
▸ POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethanesulfonic Acid SCHEMBL28934087 0.86 PTGS2 (0.34) HCRTR1HCRTR2
SCHEMBL27899616 0.76 MEN1 (0.39) HCRTR1HCRTR2BRD9MEN1KMT2A
SCHEMBL22323697 0.75 ALDH1A1 (0.50) HCRTR1HCRTR2MEN1KMT2ANPC1
Hydrochloric Acid SCHEMBL5384716 0.73 ALDH1A1 (0.47) MEN1KMT2ANPC1RAB9AALDH1A1
Hydrochloric Acid SCHEMBL1855131 0.73 MEN1 (0.53) HCRTR1MEN1KMT2ANPC1RAB9A
SCHEMBL22323949 0.72 ENPP2 (0.43) HCRTR1HCRTR2ALDH1A1
SCHEMBL29447077 0.72 ENPP2 (0.43) HCRTR1HCRTR2ALDH1A1
SCHEMBL10511000 0.72 SIRT6 (0.45) MEN1KMT2ANPC1RAB9AALDH1A1
Hydrochloric Acid SCHEMBL7134410 0.72 MEN1 (0.52) HCRTR1MEN1KMT2ANPC1RAB9A
Hydrochloric Acid SCHEMBL8498491 0.72 CA1 (0.54) MEN1KMT2ACYP2C9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230020922-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-01-19 — — US disclosed
EP-3920926-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING Skyhawk Therapeutics, Inc. (US) 2021-12-15 — — EP disclosed
WO-2020163541-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. (US) 2020-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230020922-A1 METHODS AND COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SNRPA1 HCRTR1 4453/4885HCRTR2 4584/4885G6PD 2153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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