Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.34 |
| ▸ | NOS3 | P29474 | 6/20 | 0.33 |
| ▸ | NOS1 | P29475 | 6/20 | 0.33 |
| ▸ | NOS2 | P35228 | 6/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728386 | 0.83 | OPRL1 (0.36) | PTGDR2OPRL1 | |
| SCHEMBL22728362 | 0.80 | SLC6A4 (0.34) | OPRL1MEN1KMT2A | |
| SCHEMBL22728365 | 0.78 | SLC6A4 (0.37) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL22728312 | 0.77 | PYCR1 (0.42) | — | |
| SCHEMBL15818896 | 0.69 | CYP2A6 (0.43) | KDM4CPTGDR2PTGDRNOS3NOS1 | |
| SCHEMBL31112014 | 0.69 | KDM4C (0.42) | KDM4CPTGDR2PTGDROPRL1PTGER2 | |
| SCHEMBL1155817 | 0.68 | KDM4C (0.48) | KDM4CPTGDR2PTGDRPTGER2TAAR1 | |
| SCHEMBL22728398 | 0.67 | PNMT (0.43) | KMT2ATAAR1 | |
| SCHEMBL15823273 | 0.67 | VCAM1 (0.44) | NOS3NOS1NOS2TAAR1 | |
| SCHEMBL22728334 | 0.64 | RIPK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |