SCHEMBL2273000

SCHEMBL2273000

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1csc(-c2ccccc2)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 3/20 0.57
TDP1 Q9NUW8 2/20 0.56
LMNA P02545 2/20 0.55
HDAC1 Q13547 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
MAPT P10636 3/20 0.52
ATM Q13315 2/20 0.52
NPSR1 Q6W5P4 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
NPY1R P25929 1/20 0.52
NPY2R P49146 1/20 0.52
GAA P10253 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
HPGD P15428 1/20 0.52
KMT2A Q03164 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TLR7 Q9NYK1 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2770989 0.82 TDP1 (0.68) CHEK1TDP1LMNAHDAC1HDAC8
SCHEMBL2278060 0.77 KMO (0.51) SMN1; SMN2PYGLPYGMNPC1RAB9A
SCHEMBL2270621 0.77 GALK1 (0.68) TDP1PYGLPYGMNPC1RAB9A
SCHEMBL12900090 0.76 RAB9A (0.54) CHEK1TDP1LMNAHDAC1HDAC8
SCHEMBL2271588 0.76 SERPINE1 (0.64) TDP1MAPTMEN1KMT2APYGL
SCHEMBL2275030 0.76 MEN1 (0.61) LMNAHDAC1MAPTNPSR1L3MBTL1
SCHEMBL2272800 0.76 HTT (0.52) MAPTL3MBTL1GAAKDM4EMEN1
SCHEMBL2272461 0.75 SMN1; SMN2 (0.55) TDP1LMNAMAPTKDM4EMEN1
SCHEMBL2275544 0.75 FABP1 (0.61) TDP1MEN1KMT2APYGMNPC1
SCHEMBL2274595 0.75 LMNA (0.70) TDP1LMNAHDAC1MAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 CHEK1 4352/4885TDP1 3823/4885LMNA 3235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.