SCHEMBL2273479

SCHEMBL2273479

O=C(O)c1ccc(CCc2ccccc2)cc1NC(=O)c1c(F)cccc1F

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
PLK1 P53350 4/20 0.46
PLK3 Q9H4B4 2/20 0.46
GRIK1 P39086 1/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
HCAR2 Q8TDS4 4/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
PCSK9 Q8NBP7 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PKM P14618 1/20 0.43
LTC4S Q16873 1/20 0.42
MCL1 Q07820 1/20 0.42
BCL2A1 Q16548 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276434 0.88 RAB9A (0.55) NPC1RAB9AGRIK1MEN1KMT2A
SCHEMBL2275745 0.85 NPC1 (0.56) NPC1RAB9AGRIK1MEN1KMT2A
SCHEMBL2269795 0.85 SLC16A3 (0.55) NPC1RAB9APLK1GRIK1MEN1
SCHEMBL2270587 0.85 LTC4S (0.48) NPC1PLK1PLK3GRIK1MEN1
SCHEMBL2271263 0.84 NPC1 (0.53) NPC1RAB9AMEN1KMT2AHCAR2
SCHEMBL2276254 0.82 CA12 (0.48) PLK1PLK3GRIK1MEN1KMT2A
SCHEMBL2275929 0.82 KMT2A (0.62) PLK1PLK3GRIK1MEN1KMT2A
SCHEMBL2271933 0.82 MEN1 (0.54) NPC1RAB9APLK1PLK3GRIK1
SCHEMBL2271080 0.81 MEN1 (0.56) NPC1RAB9APLK1PLK3GRIK1
SCHEMBL2271570 0.80 ACLY (0.60) GRIK1MEN1KMT2AHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 NPC1 4836/4885RAB9A 2238/4885PLK1 4227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.