SCHEMBL2270239

SCHEMBL2270239

O=C(Nc1cc(OC2=COC(Cc3ccccc3)O2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PYGM P11217 6/20 0.46
PYGL P06737 5/20 0.46
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
PKM P14618 3/20 0.43
MAPT P10636 1/20 0.43
GRIK1 P39086 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
LTC4S Q16873 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
SERPINE1 P05121 1/20 0.40
KCNK2 O95069 1/20 0.39
KCNK10 P57789 1/20 0.39
MCL1 Q07820 1/20 0.39
BCL2A1 Q16548 1/20 0.39
HPSE Q9Y251 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1656726 0.84 POLB (0.45) PYGMPYGLTDP1MCL1HPSE
SCHEMBL2267869 0.83 CYP2C9 (0.45) PYGMPYGLKMT2AMAPTSMN1; SMN2
SCHEMBL2274797 0.81 MEN1 (0.46) MEN1KMT2APKMMAPTGRIK1
SCHEMBL2276077 0.77 PRSS12 (0.43) MEN1KMT2APKMMAPTGRIK1
SCHEMBL2271588 0.75 SERPINE1 (0.64) PYGMPYGLMEN1KMT2APKM
SCHEMBL7128829 0.74 PYGL (0.55) PYGMPYGL
SCHEMBL2272855 0.74 HDAC2 (0.43) MEN1KMT2APKMMAPTGRIK1
SCHEMBL2275173 0.73 SMN1; SMN2 (0.63) MEN1KMT2APKMMAPTGRIK1
SCHEMBL2272946 0.73 ACLY (0.48) KMT2ANPC1RAB9AKCNK2KCNK10
SCHEMBL2278113 0.73 NPC1 (0.39) MEN1KMT2APKMMAPTGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PYGM 1299/4885PYGL 1834/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.