SCHEMBL2288397

SCHEMBL2288397

Cc1ccc(C(NCCCCC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 6/20 0.57
▸ MDM4 O15151 2/20 0.49
▸ TP53 P04637 2/20 0.49
▸ TLR2 O60603 2/20 0.46
▸ KMT2A Q03164 1/20 0.45
▸ TGM2 P21980 1/20 0.44
▸ CASP3 P42574 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6158363 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL436024 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL29547181 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL29792115 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL31681399 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL29362301 1.00 MDM2 (0.57) MDM2MDM4TP53TLR2KMT2A
SCHEMBL21192401 0.97 MDM2 (0.58) MDM2MDM4TP53TLR2KMT2A
SCHEMBL5967470 0.97 MDM2 (0.58) MDM2MDM4TP53TLR2KMT2A
SCHEMBL29401280 0.97 MDM2 (0.58) MDM2MDM4TP53TLR2KMT2A
SCHEMBL31614333 0.94 MDM2 (0.53) MDM2MDM4TP53TLR2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3355931-B1 PROTEIN CONJUGATES NOVO NORDISK AS (DK) 2024-06-26 — — EP disclosed
CN-106139158-B Growth hormone with prolonged in vivo efficacy 诺沃—诺迪斯克保健股份有限公司 2024-06-21 — — CN disclosed
US-20240174622-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND NIHON MEDI-PHYSICS CO., LTD. (JP) 2024-05-30 — — US disclosed
EP-4303213-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND Nihon Medi-Physics Co., Ltd. (JP) 2024-01-10 — — EP disclosed
CN-117377759-A Self-purified nucleic acid-encoded libraries 约尔格·谢尔曼 2024-01-09 — — CN disclosed
US-11674136-B2 DNA-templated macrocycle library PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-13 — — US disclosed
US-20230112418-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND NIHON MEDI-PHYSICS CO., LTD. (JP) 2023-04-13 — — US disclosed
EP-4116306-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND Nihon Medi-Physics Co., Ltd (JP) 2023-01-11 — — EP disclosed
US-20220411461-A1 METHODS OF MAKING INCRETIN ANALOGS ELI LILLY AND COMPANY 2022-12-29 — — US disclosed
WO-2022186311-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND 日本メジフィジックス株式会社 2022-09-09 — — WO disclosed
US-8779109-B2 Growth hormones with prolonged in-vivo efficacy NOVO NORDISK HEALTH CARE AG (CH) 2014-07-15 — — US disclosed
US-20140107324-A1 Growth Hormones with Prolonged In-Vivo Efficacy NOVO NORDISK HEALTH CARE AG (CH) 2014-04-17 — — US disclosed
CN-103269720-A Growth hormone conjugates NOVO NORDISK HEALTHCARE AG 2013-08-28 — — CN disclosed
CN-103002918-A Growth hormone with prolonged in vivo efficacy NOVO NORDISK HEALTHCARE AG 2013-03-27 — — CN disclosed
US-20120309944-A1 Growth Hormones With Prolonged In-Vivo Efficacy NOVO NORDISK HEALTH CARE AG (CH) 2012-12-06 — — US disclosed
EP-2525834-A1 GROWTH HORMONES WITH PROLONGED IN-VIVO EFFICACY Novo Nordisk Health Care AG (CH) 2012-11-28 — — EP disclosed
CN-102612376-A Growth hormone with prolonged in vivo efficacy NOVO NORDISK HEALTHCARE AG 2012-07-25 — — CN disclosed
US-20120172303-A1 Growth Hormones with Prolonged In-Vivo Efficacy NOVO NORDISK HEALTH CARE AG (CH) 2012-07-05 — — US disclosed
US-20110223151-A1 CONJUGATED PROTEINS WITH PROLONGED IN VIVO EFFICACY NOVO NORDISK HEALTH CARE AG (CH) 2011-09-15 — — US disclosed
WO-2011089255-A1 GROWTH HORMONES WITH PROLONGED IN-VIVO EFFICACY NOVO NORDISK HEALTH CARE AG (CH) 2011-07-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120172303-A1 Growth Hormones with Prolonged In-Vivo Efficacy GHRHR, GHITM, SHBG MDM2 260/4885MDM4 3463/4885TP53 1051/4885
US-11674136-B2 DNA-templated macrocycle library IDE, IAPP, POLRMT MDM2 938/4885MDM4 1827/4885TP53 130/4885
US-20120309944-A1 Growth Hormones With Prolonged In-Vivo Efficacy GHRHR, SHBG, GHSR MDM2 179/4885MDM4 1988/4885TP53 403/4885
US-20230112418-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND ALB, TFRC, FABP2 MDM2 717/4885MDM4 1173/4885TP53 209/4885
US-20140107324-A1 Growth Hormones with Prolonged In-Vivo Efficacy SHBG, GHRHR, GHITM MDM2 180/4885MDM4 1876/4885TP53 796/4885
US-20240174622-A1 COMPOUND AND RADIOACTIVE LABELING COMPOUND PSMA2, PSMA1, PSMA3 MDM2 191/4885MDM4 386/4885TP53 1163/4885
US-20220411461-A1 METHODS OF MAKING INCRETIN ANALOGS IAPP, GLP1R, GIPR MDM2 2077/4885MDM4 4057/4885TP53 4065/4885
US-20110223151-A1 CONJUGATED PROTEINS WITH PROLONGED IN VIVO EFFICACY F13B, F13A1, F2 MDM2 3834/4885MDM4 4759/4885TP53 3129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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