SCHEMBL22888

SCHEMBL22888

CCOC1CCN(c2ccc(Cl)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.50
KDM4E B2RXH2 2/20 0.45
GAA P10253 1/20 0.45
CCR5 P51681 1/20 0.44
HTR3E A5X5Y0 1/20 0.44
HTR3B O95264 1/20 0.44
ADRB1 P08588 1/20 0.44
HTR3A P46098 1/20 0.44
HTR3D Q70Z44 1/20 0.44
HTR3C Q8WXA8 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
NOTUM Q6P988 1/20 0.43
CARM1 Q86X55 1/20 0.43
PRMT6 Q96LA8 1/20 0.43
CHIA Q9BZP6 1/20 0.42
LTA4H P09960 2/20 0.41
CCR1 P32246 1/20 0.41
DRD4 P21917 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5311598 0.83 MAPT (0.53) KMT2AKDM4EGAASMN1; SMN2MEN1
SCHEMBL293214 0.81 HTR3E (0.48) KMT2AKDM4EGAAHTR3EHTR3B
SCHEMBL6134370 0.80 CHRNA10 (0.52) KDM4EMEN1
SCHEMBL1664730 0.78 USP2 (0.63) KDM4EGAAADRB1SMN1; SMN2LMNA
SCHEMBL13279724 0.77 CARM1 (0.53) KMT2AGAANOTUMCARM1PRMT6
SCHEMBL5314836 0.77 MAPT (0.64) KMT2AADRB1SMN1; SMN2MEN1LMNA
SCHEMBL22597892 0.76 POLB (0.56) KMT2AKDM4EGAACCR5MEN1
SCHEMBL5846178 0.75 HCRTR2 (0.47) KDM4EADRB1NOTUMCARM1PRMT6
SCHEMBL10162755 0.75 KMT2A (0.40) KMT2AKDM4EGAACARM1PRMT6
SCHEMBL24681616 0.75 NOTUM (0.51) KMT2AHTR3EHTR3BADRB1HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 US claimed
CN-106977567-B Oligonucleotide with protected base moiety 味之素株式会社 2021-02-02 CN claimed
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2019-05-14 US claimed
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-11-24 US claimed
EP-2334692-B1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS UNIV MCGILL (CA) 2016-04-13 EP claimed
US-9249175-B2 RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-02-02 US claimed
US-20120178638-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-07-12 US claimed
EP-2334692-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS The Royal Institution for the Advancement of Learning / McGill University (CA) 2011-06-22 EP claimed
WO-2010025566-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2010-03-11 WO claimed
WO-2024073349-A2 CLEAVABLE LINKERS FOR THE TETHERING OF POLYMERASES TO NUCLEOTIDES ANSA BIOTECHNOLOGIES, INC. (US) 2024-04-04 WO disclosed
CN-110337495-B Single-stranded oligonucleotides 日产化学株式会社 2024-03-29 CN disclosed
US-20240084296-A1 SINGLE-STRANDED OLIGONUCLEOTIDE NISSAN CHEMICAL CORPORATION (JP) 2024-03-14 US disclosed
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2024-01-18 US disclosed
EP-4293035-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2023-12-20 EP disclosed
WO-2010025566-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2010-03-11 WO disclosed
WO-2009064115-A1 PREPARATION OF NUCLEOTIDE OLIGOMER SAMCHULLY PHARM. CO., LTD. (KR) 2009-05-22 WO disclosed
EP-1899467-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceutical GmbH (DE) 2008-03-19 EP disclosed
US-20080064867-A1 PROCESS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES SIGMA ALDRICH COMPANY (US) 2008-03-13 US disclosed
WO-2006116458-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY COLEY PHARMACEUTICAL GMBH (DE) 2006-11-02 WO disclosed
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2006-10-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays EFTUD2, RNMT, NSUN2 KMT2A 1798/4885KDM4E 924/4885GAA 1382/4885
US-20080064867-A1 PROCESS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES RNGTT, DUT, ADAR KMT2A 1866/4885KDM4E 1717/4885GAA 661/4885
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS EFTUD2, RNMT, RNGTT KMT2A 1746/4885KDM4E 911/4885GAA 1477/4885
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity TLR3, TLR8, TLR9 KMT2A 765/4885KDM4E 1276/4885GAA 1137/4885
US-20240084296-A1 SINGLE-STRANDED OLIGONUCLEOTIDE MLX, ZFX, UPF1 KMT2A 1960/4885KDM4E 2321/4885GAA 1551/4885
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD RNGTT, NOX4, POLRMT KMT2A 2534/4885KDM4E 3319/4885GAA 3338/4885
US-20120178638-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS EFTUD2, RNMT, RNGTT KMT2A 1746/4885KDM4E 911/4885GAA 1477/4885
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES POLN, POLRMT, POLI KMT2A 3340/4885KDM4E 4513/4885GAA 2244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.