Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25399754 | 0.88 | HTR2A (0.55) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL30501959 | 0.88 | HTR2A (0.55) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL14021954 | 0.84 | KDM4E (0.48) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL19192790 | 0.81 | SMN1; SMN2 (0.53) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL23259127 | 0.81 | HTR7 (0.60) | KDM4EGAAHTR2AHTR2CLMNA | |
| SCHEMBL23259133 | 0.80 | KIF11 (0.47) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL24453687 | 0.78 | HTR6 (0.65) | KDM4EGAAHTR2AHTR2CLMNA | |
| SCHEMBL26996508 | 0.78 | HTR2A (0.39) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL15150611 | 0.77 | HTR6 (0.46) | KIF11KEAP1NFE2L2KDM4EGAA | |
| SCHEMBL31534095 | 0.77 | ALDH1A1 (0.61) | KIF11KEAP1NFE2L2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873305-B2 | Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds | GENENTECH, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20220162186-A1 | PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, AND USES RELATED THERETO | EMORY UNIVERSITY | 2022-05-26 | — | — | US | disclosed |
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| WO-2021074898-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-04-22 | — | — | WO | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | KIF11 3144/4885KEAP1 79/4885NFE2L2 494/4885 |
| US-11873305-B2 | Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds | WEE1, WEE2, INMT | KIF11 3824/4885KEAP1 2257/4885NFE2L2 2224/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | KIF11 3175/4885KEAP1 147/4885NFE2L2 1349/4885 |
| US-20220162186-A1 | PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, AND USES RELATED THERETO | PTGER2, PTGES2, PTGES | KIF11 4757/4885KEAP1 1663/4885NFE2L2 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.