SCHEMBL2386145

SCHEMBL2386145

COC(=O)C[C@@H](C)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.33
HSD17B10 Q99714 1/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
TET2 Q6N021 1/20 0.31
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5631757 1.00 TSHR (0.33) TSHRHSD17B10MGAMGAASI
SCHEMBL14418876 0.85
SCHEMBL15653580 0.83 TSHR (0.34) TSHRHSD17B10MGAMGAASI
SCHEMBL12638742 0.82 GAA (0.38) TSHRHSD17B10MGAMGAASI
SCHEMBL14667853 0.82 GAA (0.38) TSHRHSD17B10MGAMGAASI
SCHEMBL9622013 0.82
SCHEMBL6496531 0.81 ALDH1A1 (0.39)
SCHEMBL4180699 0.81 PGD (0.33)
SCHEMBL4180706 0.81 PGD (0.33)
SCHEMBL6484089 0.81 ALDH1A1 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103475-A1 MAP4K1 INHIBITORS BLUEPRINT MEDICINES CORP (US) 2026-04-16 US disclosed
US-20250270209-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. 2025-08-28 US disclosed
EP-4522615-A1 LRRK2 INHIBITORS Interline Therapeutics, Inc. (US) 2025-03-19 EP disclosed
EP-4522616-A1 LRRK2 INHIBITORS Interline Therapeutics, Inc. (US) 2025-03-19 EP disclosed
US-20250066356-A1 LRRK2 INHIBITORS INTERLINE THERAPEUTICS, INC. 2025-02-27 US disclosed
US-12202844-B2 MAP4K1 inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2025-01-21 US disclosed
EP-3634430-B1 MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME FLAGSHIP PIONEERING INNOVATIONS V INC (US) 2024-08-07 EP disclosed
US-12037354-B2 Cyclic pantetheine derivatives and uses thereof VECTIVBIO COMET AG (CH) 2024-07-16 US disclosed
US-12037354-B2 Cyclic pantetheine derivatives and uses thereof VECTIVBIO COMET AG (CH) 2024-07-16 US disclosed
EP-4370523-A1 HETEROCYCLIC COMPOUNDS AS MAP4K1 INHIBITORS Blueprint Medicines Corporation (US) 2024-05-22 EP disclosed
US-20140329771-A1 STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN INSTITUT PASTEUR (FR) 2014-11-06 US disclosed
US-8471048-B2 Ruthenium carbonyl complex having tridentate ligand, its production method and use TAKASAGO INTERNATIONAL CORPORATION (JP) 2013-06-25 US disclosed
US-8471048-B2 Ruthenium carbonyl complex having tridentate ligand, its production method and use TAKASAGO INTERNATIONAL CORPORATION (JP) 2013-06-25 US disclosed
WO-2013072896-A1 STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN INSTITUT PASTEUR (FR) 2013-05-23 WO disclosed
EP-2594561-A1 Structural variants of mycolactones for use in modulating inflammation, immunity and pain INSTITUT PASTEUR (FR) 2013-05-22 EP disclosed
US-20120310000-A1 ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME PORTON FINE CHEMICALS LTD. (CN) 2012-12-06 US disclosed
US-20110237814-A1 NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE TAKASAGO INTERNATIONAL CORPORATION (JP) 2011-09-29 US disclosed
US-20110237814-A1 NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE TAKASAGO INTERNATIONAL CORPORATION (JP) 2011-09-29 US disclosed
EP-0269236-B1 PROCESS FOR SYNTHESIS OF A CHIRAL AZETIDINONE MERCK & CO. INC. (US) 1991-04-03 EP disclosed
EP-0269236-A1 Process for synthesis of a chiral azetidinone MERCK & CO. INC. (US) 1988-06-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140329771-A1 STRUCTURAL VARIANTS OF MYCOLACTONES FOR USE IN MODULATING INFLAMMATION, IMMUNITY AND PAIN IL1B, MYC, IL1A TSHR 4844/4885HSD17B10 1059/4885MGAM 727/4885
US-12202844-B2 MAP4K1 inhibitors MAP4K1, MAP4K4, MAP4K2 TSHR 4610/4885HSD17B10 2621/4885MGAM 3472/4885
US-20250066356-A1 LRRK2 INHIBITORS LRRK2, PARK7, PINK1 TSHR 4664/4885HSD17B10 3433/4885MGAM 3200/4885
US-20260103475-A1 MAP4K1 INHIBITORS MAP4K1, MAP3K4, MAP4K4 TSHR 3148/4885HSD17B10 3016/4885MGAM 4659/4885
US-20120310000-A1 ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME ROS1, KCNN2, KCNN4 TSHR 3934/4885HSD17B10 724/4885MGAM 1217/4885
US-12037354-B2 Cyclic pantetheine derivatives and uses thereof VNN1, VKORC1, PANK3 TSHR 3245/4885HSD17B10 596/4885MGAM 1946/4885
US-20250270209-A1 LRRK2 INHIBITORS LRRK2, PARK7, PINK1 TSHR 4664/4885HSD17B10 3433/4885MGAM 3200/4885
US-20110237814-A1 NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE ADH1C, ADH1A, ADH5 TSHR 1289/4885HSD17B10 354/4885MGAM 1792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.