Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011270 | 0.86 | PKM (0.45) | PKMALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL24011556 | 0.83 | ACHE (0.49) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24011384 | 0.83 | SMN1; SMN2 (0.60) | PKMALDH1A1LMNATSHRPOLB | |
| SCHEMBL24011413 | 0.80 | PKM (0.39) | PKMALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL24011627 | 0.79 | MEN1 (0.46) | ALDH1A1KDM4EMTNR1BPOLBSMN1; SMN2 | |
| SCHEMBL24011561 | 0.78 | THRB (0.57) | ALDH1A1LMNAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL24011636 | 0.78 | ADAM17 (0.46) | PKMALDH1A1LMNAMAPT | |
| SCHEMBL24011251 | 0.78 | ADAM17 (0.47) | ALDH1A1LMNARAB9A | |
| SCHEMBL24011363 | 0.75 | LMNA (0.54) | ALDH1A1KDM4ELMNAMAPTL3MBTL1 | |
| SCHEMBL26633693 | 0.73 | SMN1; SMN2 (0.53) | PKMALDH1A1LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |