Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011041 | 0.84 | THRB (0.61) | THRBTP53ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL24011567 | 0.78 | PKM (0.43) | ALDH1A1MAPTLMNAPOLBNPC1 | |
| SCHEMBL24011556 | 0.78 | ACHE (0.49) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL24011270 | 0.76 | PKM (0.45) | ALDH1A1MAPTLMNA | |
| SCHEMBL26633866 | 0.76 | THRB (0.57) | THRBTP53ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL24011251 | 0.76 | ADAM17 (0.47) | ALDH1A1LMNARAB9A | |
| SCHEMBL24011627 | 0.73 | MEN1 (0.46) | ALDH1A1CYP3A4CYP2D6POLBSMN1; SMN2 | |
| SCHEMBL24011413 | 0.73 | PKM (0.39) | ALDH1A1MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL24011636 | 0.72 | ADAM17 (0.46) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL24011363 | 0.71 | LMNA (0.54) | ALDH1A1MAPTLMNANPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |