Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252374 | 0.99 | ROCK2 (0.32) | ROCK2ROCK1CDC42BPBPRMT5WDR77 | |
| SCHEMBL24252229 | 0.88 | LRRK2 (0.35) | — | |
| SCHEMBL24252407 | 0.76 | GSK3B (0.40) | ROCK2ROCK1CDC42BPBOPRK1 | |
| SCHEMBL24252377 | 0.76 | HRH3 (0.35) | — | |
| SCHEMBL24252414 | 0.75 | GSK3B (0.38) | ROCK2ROCK1CDC42BPB | |
| SCHEMBL24252378 | 0.75 | LMNA (0.35) | — | |
| SCHEMBL24252215 | 0.74 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL24252373 | 0.73 | HDAC4 (0.33) | PRMT5WDR77 | |
| SCHEMBL24252217 | 0.70 | — | — | |
| SCHEMBL24252375 | 0.70 | CYP2C8 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034203-A1 | PROCESS FOR THE PREPARATION OF PYRIDAZINONE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2022-02-17 | — | — | WO | disclosed |