SCHEMBL24252518

SCHEMBL24252518

CC(C)Cc1cncc(Br)c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
POLB P06746 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
TACR1 P25103 1/20 0.33
SLC6A4 P31645 1/20 0.33
KCNH2 Q12809 1/20 0.33
PKM P14618 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP2A6 P11509 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14557688 0.84 GABRA1 (0.39) MAPTPOLBKDM4EGABRA1GABRB2
SCHEMBL5144552 0.84 HTT (0.39) MAPTHTTSMN1; SMN2POLBHCAR2
SCHEMBL8435109 0.84 HTT (0.36) MAPTHTTSMN1; SMN2POLBHCAR2
SCHEMBL16213437 0.81 TACR1 (0.36) MAPTHTTSMN1; SMN2POLBHCAR2
SCHEMBL26614750 0.79 POLB (0.35) MAPTHTTSMN1; SMN2POLBHCAR2
SCHEMBL13534147 0.77 GPR55 (0.35) MAPTHTTSMN1; SMN2GABRA1GABRB2
SCHEMBL14983862 0.77 CYP11B1 (0.39) HCAR2
SCHEMBL30846835 0.76 NOS1 (0.34) GABRA1GABRB2
SCHEMBL27209028 0.76 NOS1 (0.34) GABRA1GABRB2
SCHEMBL670394 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4327877-A2 DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY XRad Therapeutics, Inc. (US) 2024-02-28 EP disclosed
US-20230303494-A1 BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF ACADEMY OF MILITARY MEDICAL SCIENCES (CN) 2023-09-28 US disclosed
EP-3743430-B1 AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 EP disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
EP-4198017-A1 BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF Academy of Military Medical Sciences (CN) 2023-06-21 EP disclosed
WO-2022033303-A1 BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF 中国人民解放军军事科学院军事医学研究院 2022-02-17 WO disclosed
US-20180222891-A1 3-(1H-INDOL-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2018-08-09 US disclosed
US-20180221350-A1 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2018-08-09 US disclosed
US-20180222923-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B] PYRIDINES AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2018-08-09 US disclosed
US-20180221353-A1 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2018-08-09 US disclosed
US-9012472-B2 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2015-04-21 US disclosed
US-8987298-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2015-03-24 US disclosed
US-20150072981-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2015-03-12 US disclosed
US-8883822-B2 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2014-11-11 US disclosed
US-20140194441-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2014-07-10 US disclosed
US-20140179696-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2014-06-26 US disclosed
US-8673936-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2014-03-18 US disclosed
US-8664241-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof SAMUMED, LLC (US) 2014-03-04 US disclosed
US-20130296302-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-11-07 US disclosed
US-20130267495-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180222891-A1 3-(1H-INDOL-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 1433/4885HTT 1260/4885SMN1; SMN2 2011/4885
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A MAPT 154/4885HTT 835/4885SMN1; SMN2 3885/4885
US-20230303494-A1 BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF CD274, PDCD1, PDCD1LG2 MAPT 2862/4885HTT 3817/4885SMN1; SMN2 3374/4885
US-20140179696-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 154/4885HTT 835/4885SMN1; SMN2 3885/4885
US-20130296302-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF COL1A1, NOX4, FGF1 MAPT 107/4885HTT 1498/4885SMN1; SMN2 654/4885
US-20180221350-A1 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 1895/4885HTT 2290/4885SMN1; SMN2 1842/4885
US-20150072981-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF COL1A1, NOX4, FGF1 MAPT 107/4885HTT 1498/4885SMN1; SMN2 654/4885
US-20140194441-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 134/4885HTT 827/4885SMN1; SMN2 2618/4885
US-20180222923-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B] PYRIDINES AND THERAPEUTIC USES THEREOF WNT1, WNT3A, WNT3 MAPT 3198/4885HTT 3142/4885SMN1; SMN2 2475/4885
US-20180221353-A1 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 3165/4885HTT 3298/4885SMN1; SMN2 2283/4885
US-20130267495-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MAPT 154/4885HTT 835/4885SMN1; SMN2 3885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.