Water

Water

SCHEMBL2446952

Nc1ccc(-c2ccccc2N)cc1.O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.52
DHFR known ✓ P00374 1/20 0.42
MEN1 known ✓ O00255 3/20 0.40
KIT known ✓ P10721 2/20 0.40
KDR known ✓ P35968 2/20 0.40
FLT3 known ✓ P36888 2/20 0.40
OPRK1 known ✓ P41145 1/20 0.40
HDAC3 known ✓ O15379 1/20 0.39
HDAC4 known ✓ P56524 1/20 0.39
HDAC1 known ✓ Q13547 1/20 0.39
HDAC7 known ✓ Q8WUI4 1/20 0.39
HDAC2 known ✓ Q92769 1/20 0.39
HDAC10 known ✓ Q969S8 1/20 0.39
HDAC11 known ✓ Q96DB2 1/20 0.39
HDAC8 known ✓ Q9BY41 1/20 0.39
HDAC6 known ✓ Q9UBN7 1/20 0.39
HDAC9 known ✓ Q9UKV0 1/20 0.39
HDAC5 known ✓ Q9UQL6 1/20 0.39
ALDH1A1 P00352 4/20 0.68
HSD17B10 Q99714 3/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29510158 0.97 ALDH1A1 (0.71) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
SCHEMBL599657 0.97 ALDH1A1 (0.71) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
SCHEMBL31264297 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
Hydrogen Sulfide SCHEMBL34563 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
Methane SCHEMBL3050883 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
SCHEMBL7141191 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
Hydrogen Sulfide SCHEMBL3678041 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
SCHEMBL29471400 0.95 ALDH1A1 (0.68) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
Biphenyl-4-Amine SCHEMBL6081432 0.91 ALDH1A1 (0.77) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1
Benzidine SCHEMBL28123514 0.91 ALDH1A1 (0.77) ALDH1A1HSD17B10L3MBTL1CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2128193-B1 POROUS POLYIMIDE IBIDEN CO LTD (JP) 2013-06-19 EP disclosed
US-8022110-B2 Porous polyimide IBIDEN CO., LTD. (JP) 2011-09-20 US disclosed
US-20100048745-A1 POROUS POLYIMIDE IBIDEN CO., LTD (JP) 2010-02-25 US disclosed
EP-2128193-A1 POROUS POLYIMIDE Ibiden Co., Ltd. (JP) 2009-12-02 EP disclosed