Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1227449 | 0.93 | LMNA (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL1226946 | 0.91 | ACP3 (0.35) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL1227055 | 0.89 | ACP3 (0.34) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Bromide SCHEMBL6873657 | 0.81 | GGPS1 (0.35) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Bromide SCHEMBL6874660 | 0.81 | KDM4E (0.31) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL6442055 | 0.79 | PABPC1 (0.43) | PABPC1APOBEC3AEIF4HAPOBEC3GLMNA | |
| SCHEMBL4330742 | 0.76 | MMP8 (0.37) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Bromide SCHEMBL6872242 | 0.76 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL2263262 | 0.74 | MMP8 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL2264607 | 0.73 | MMP2 (0.37) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999430-B2 | Method of manufacturing display element | KONICA MINOLTA HOLDINGS, INC. (JP) | 2015-04-07 | — | — | US | disclosed |
| EP-2149816-B1 | METHOD OF MANUFACTURING AN ELECTROCHROMIC DISPLAY ELEMENT | KONICA MINOLTA HOLDINGS INC (JP) | 2014-05-07 | — | — | EP | disclosed |
| US-8014056-B2 | Display element and method of driving the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| US-20100166946-A1 | METHOD OF MANUFACTURING DISPLAY ELEMENT | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2149816-A1 | METHOD FOR PRODUCTION OF DISPLAY ELEMENT | Konica Minolta Holdings, Inc. (JP) | 2010-02-03 | — | — | EP | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |