Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | PTPRS | Q13332 | 1/20 | 1.00 |
| ▸ | RGS17 | Q9UGC6 | 1/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17885706 | 0.90 | ALDH1A1 (0.81) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL16432690 | 0.88 | ALOX15 (0.78) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL737653 | 0.86 | ALDH1A1 (0.75) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL13279932 | 0.86 | MAPT (0.75) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL30525493 | 0.86 | MAPT (0.75) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL3385694 | 0.82 | ALDH1A1 (0.68) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL28740045 | 0.81 | PTPN1 (0.70) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL29931737 | 0.80 | ABCB1 (0.75) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL27757185 | 0.76 | CYP3A4 (0.70) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| Irigenin SCHEMBL30335091 | 0.75 | EGFR (0.72) | MAPTMEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264616-A1 | THERAPEUTIC COMPOUNDS AND METHODS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-09-15 | — | — | US | claimed |
| EP-2367522-A2 | METHOD AND COMPOSITION FOR SKIN COLOR MODULATION | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House (GB) | 2011-09-28 | — | — | EP | claimed |
| WO-2010072805-A2 | METHOD AND COMPOSITION FOR COLOR MODULATION | UNILEVER PLC (GB) | 2010-07-01 | — | — | WO | claimed |
| US-20100158829-A1 | Method and Composition for Color Modulation | CONOPCO, INC., D/B/A UNILEVER (US) | 2010-06-24 | — | — | US | claimed |
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527878-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | NUTECH VENTURES | 2016-10-27 | — | — | US | disclosed |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | NUTECH VENTURES | 2016-10-27 | — | — | US | disclosed |
| US-20160264616-A1 | THERAPEUTIC COMPOUNDS AND METHODS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264616-A1 | THERAPEUTIC COMPOUNDS AND METHODS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264616-A1 | THERAPEUTIC COMPOUNDS AND METHODS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160185843-A1 | TREATING ALCOHOL-MEDIATED DISORDERS BY INHIBITION OF RGS6 | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-06-30 | — | — | US | disclosed |
| CN-105101964-A | Use of selective opioid receptor antagonists and specific sensory ligands | BIGLIARDI PAUL | 2015-11-25 | — | — | CN | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | YALE UNIVERSITY (US) | 2015-10-01 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| EP-2367522-A2 | METHOD AND COMPOSITION FOR SKIN COLOR MODULATION | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House (GB) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010072805-A2 | METHOD AND COMPOSITION FOR COLOR MODULATION | UNILEVER PLC (GB) | 2010-07-01 | — | — | WO | disclosed |
| US-20100158829-A1 | Method and Composition for Color Modulation | CONOPCO, INC., D/B/A UNILEVER (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | MAPT 3350/4885MEN1 1398/4885KMT2A 3410/4885 |
| US-20100158829-A1 | Method and Composition for Color Modulation | TYR, TH, COMT | MAPT 24/4885MEN1 3892/4885KMT2A 1409/4885 |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | UGDH, G6PD, DPYD | MAPT 2722/4885MEN1 2328/4885KMT2A 1415/4885 |
| US-20160185843-A1 | TREATING ALCOHOL-MEDIATED DISORDERS BY INHIBITION OF RGS6 | RGS4, RGS16, ADH1A | MAPT 2896/4885MEN1 3926/4885KMT2A 766/4885 |
| US-20160264616-A1 | THERAPEUTIC COMPOUNDS AND METHODS | RGS17, RGS16, RGS4 | MAPT 4175/4885MEN1 3073/4885KMT2A 2710/4885 |
| US-20150272939-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase | KDM1B, KDM1A, JMJD1C | MAPT 4286/4885MEN1 3296/4885KMT2A 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.