Lotilaner

Lotilaner

SCHEMBL2502148

Cc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)sc1C(=O)NCC(=O)NCC(F)(F)F

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.33
LMNA P02545 1/20 0.31
PTGES O14684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lotilaner SCHEMBL16860871 1.00 CCR1 (0.33) CCR1LMNAPTGES
SCHEMBL2505425 0.94 CCR1 (0.33) CCR1LMNA
SCHEMBL23874305 0.94 CCR1 (0.33) CCR1LMNA
SCHEMBL2496669 0.92 CCR1 (0.35) CCR1LMNA
SCHEMBL19272772 0.92 CCR1 (0.34) CCR1LMNA
SCHEMBL25586455 0.91 CCR1 (0.39) CCR1
SCHEMBL2507781 0.91 CCR1 (0.35) CCR1LMNA
SCHEMBL29224834 0.90 CCR1 (0.33) CCR1
SCHEMBL29224829 0.90 CCR1 (0.33) CCR1
SCHEMBL17734096 0.90 CCR1 (0.33) CCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110245239-A1 ORGANIC COMPOUNDS ELANCO TIERGESUNDHEIT AG (CH) 2011-10-06 US claimed
WO-2026041786-A1 INJECTABLE VETERINARY COMPOSITION AND USES THEREOF INTERVET INTERNATIONAL B.V. (NL) 2026-02-26 WO disclosed
US-20260021076-A1 ISOXAZOLINE AND MACROCYCLIC LACTONE MICROSPHERES ZOETIS SERVICES LLC (US) 2026-01-22 US disclosed
EP-4580627-A1 TREATMENT OF FASCIOLOSIS Intervet International B.V. (NL) 2025-07-09 EP disclosed
WO-2024201231-A1 A PROCESS FOR THE PREPARATION OF ISOXAZOLINE-SUBSTITUTED AMIDE COMPOUNDS AND ITS INTERMEDIATES THEREOF HIKAL LIMITED (IN) 2024-10-03 WO disclosed
EP-4358941-A1 PALATABLE VETERINARY COMPOSITIONS Intervet International B.V. (NL) 2024-05-01 EP disclosed
EP-4351341-A1 TICK CONTROL METHODS Intervet International B.V. (NL) 2024-04-17 EP disclosed
WO-2024047241-A1 TREATMENT OF FASCIOLOSIS INTERVET INTERNATIONAL B.V. (NL) 2024-03-07 WO disclosed
US-20230257370-A1 PROCESS FOR MAKING AN ISOXAZOLINE COMPOUND AND INTERMEDIATE THEREOF SHANGHAI STA PHARMACEUTICAL R&D CO., LTD. (CN) 2023-08-17 US disclosed
WO-2023012821-A1 A PROCESS FOR THE PREPARATION OF CARBAMOYL BENZAMIDE PHENYL ISOXAZOLINE CLASS DRUG/S AND ITS INTERMEDIATES ZENFOLD SUSTAINABLE TECHNOLOGIES PRIVATE LIMITED (IN) 2023-02-09 WO disclosed
US-20170208806-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-07-27 US disclosed
US-20170208805-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-07-27 US disclosed
US-20170210723-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-07-27 US disclosed
US-20170208803-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-07-27 US disclosed
US-20170208804-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-07-27 US disclosed
US-20170020848-A1 EXTENDED RELEASE INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF MERIAL INC. (US) 2017-01-26 US disclosed
US-20160317502-A1 USE OF ISOXAZOLINE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ARTHROPOD INFESTATIONS IN POULTRY INTERVET INC. (US) 2016-11-03 US disclosed
WO-2016164487-A1 EXTENDED RELEASE INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF MERIAL, INC. (US) 2016-10-13 WO disclosed
US-20160256442-A1 LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEROF MERIAL, INC. (US) 2016-09-08 US disclosed
WO-2016138339-A1 LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF MERIAL, INC. (US) 2016-09-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170208803-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 CCR1 4110/4885LMNA 3113/4885PTGES 157/4885
US-20170210723-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 CCR1 4110/4885LMNA 3113/4885PTGES 157/4885
US-20260021076-A1 ISOXAZOLINE AND MACROCYCLIC LACTONE MICROSPHERES MTX2, CYP3A7, MIF CCR1 4155/4885LMNA 901/4885PTGES 2530/4885
US-20230257370-A1 PROCESS FOR MAKING AN ISOXAZOLINE COMPOUND AND INTERMEDIATE THEREOF CYP3A7, CYP4Z1, CYP2A7 CCR1 4298/4885LMNA 1563/4885PTGES 4189/4885
US-20160256442-A1 LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEROF MACF1, RTF1, PRDX5 CCR1 1907/4885LMNA 1801/4885PTGES 552/4885
US-20160317502-A1 USE OF ISOXAZOLINE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ARTHROPOD INFESTATIONS IN POULTRY CYP4X1, XDH, CYP2A7 CCR1 4023/4885LMNA 2459/4885PTGES 2257/4885
US-20170208806-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 CCR1 4110/4885LMNA 3113/4885PTGES 157/4885
US-20110245239-A1 ORGANIC COMPOUNDS ACHE, VDAC1, VDAC2 CCR1 4087/4885LMNA 3796/4885PTGES 1056/4885
US-20170208804-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 CCR1 4110/4885LMNA 3113/4885PTGES 157/4885
US-20170208805-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MSMO1 CCR1 4110/4885LMNA 3113/4885PTGES 157/4885
US-20170020848-A1 EXTENDED RELEASE INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF IPO7, MMP1, CYP3A7 CCR1 2660/4885LMNA 1610/4885PTGES 808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.