Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 8/20 | 0.53 |
| ▸ | SERPINC1 known ✓ | P01008 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 16/20 | 0.61 |
| ▸ | FGF2 | P09038 | 5/20 | 0.47 |
| ▸ | VEGFA | P15692 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334212 | 0.80 | HPSE (0.85) | HPSEFGF1FGF2VEGFASERPINC1 | |
| SCHEMBL8781188 | 0.78 | FGF1 (0.52) | HPSEFGF1FGF2SERPINC1 | |
| SCHEMBL7064312 | 0.78 | FGF1 (0.52) | HPSEFGF1FGF2SERPINC1 | |
| SCHEMBL6344943 | 0.78 | FGF1 (0.52) | HPSEFGF1FGF2SERPINC1 | |
| SCHEMBL2507111 | 0.77 | FGF1 (0.51) | HPSEFGF1FGF2SERPINC1 | |
| SCHEMBL17781848 | 0.74 | CA2 (0.49) | HPSEFGF1SERPINC1 | |
| SCHEMBL30804122 | 0.74 | CA2 (0.49) | HPSEFGF1SERPINC1 | |
| SCHEMBL8332204 | 0.72 | HPSE (0.52) | HPSEFGF1FGF2VEGFA | |
| SCHEMBL8332214 | 0.72 | HPSE (0.63) | HPSEFGF1FGF2VEGFA | |
| SCHEMBL13925274 | 0.70 | CYP2D6 (0.40) | HPSEFGF1FGF2VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205616-B1 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES | PROGEN PHARMACEUTICALS LTD (AU) | 2016-04-27 | — | — | EP | claimed |
| EP-2205616-B1 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES | PROGEN PHARMACEUTICALS LTD (AU) | 2016-04-27 | — | — | EP | disclosed |
| US-20110245196-A1 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES | PROGEN PG500 SERIES PTY LTD (AU) | 2011-10-06 | — | — | US | disclosed |
| EP-2205616-A1 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES | Progen Pharmaceuticals Limited (AU) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009049370-A1 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES | PROGEN PHARMACEUTICALS LIMITED (AU) | 2009-04-23 | — | — | WO | disclosed |