Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.53 |
| ▸ | PDK1 known ✓ | Q15118 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL11175319 | 0.97 | ALOX5 (0.53) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL417015 | 0.85 | ALOX5 (0.58) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL310681 | 0.85 | PTPN1 (0.58) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL27588745 | 0.82 | MEN1 (0.62) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL28048457 | 0.79 | HSP90AB1 (0.56) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL6762297 | 0.78 | TDP1 (0.58) | ALOX5KMT2AALDH1A1 | |
| (Chloromethyl)Benzene SCHEMBL7198605 | 0.78 | PTPN1 (0.51) | ALOX5PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL29029109 | 0.78 | HSP90AA1 (0.55) | ALOX5GAAKDM4EALDH1A1HPGD | |
| SCHEMBL729988 | 0.78 | HSD17B1 (0.50) | HSD17B3KDM4EALDH1A1HPGD | |
| SCHEMBL10599031 | 0.77 | PTPN1 (0.49) | ALOX5PTPN1PTPN2PTPN6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2174652-B1 | ORAL PHARMACEUTICAL DESMOPRESSIN COMPOSITION | GP PHARM SA (ES) | 2016-10-05 | — | — | EP | disclosed |
| US-8993521-B2 | Oral pharmaceutical composition of desmopressin | GP PHARM, S.A. (ES) | 2015-03-31 | — | — | US | disclosed |
| US-20110251123-A1 | ORAL PHARMACEUTICAL COMPOSITION OF DESMOPRESSIN | GP PHARM, S.A. LABORATORIO REIG JOFRE, S.A. | 2011-10-13 | — | — | US | disclosed |
| EP-2174652-A2 | ORAL PHARMACEUTICAL DESMOPRESSIN COMPOSITION | GP Pharm S.A. (ES) | 2010-04-14 | — | — | EP | disclosed |