SCHEMBL25408481

SCHEMBL25408481

O=C1C=C(C(=O)[O-])CCC1.[Na+]

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MT-CO2 P00403 2/20 0.33
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2082622 0.77 OAT (0.41) MAPTALDH1A1GAASMN1; SMN2MT-CO2
SCHEMBL2081539 0.76 MT-CO2 (0.40) MAPTALDH1A1MT-CO2KMT2A
SCHEMBL2600393 0.72 CHRM3 (0.42) MAPTALDH1A1
SCHEMBL6316758 0.72 MAPT (0.48) MAPTALDH1A1GAASMN1; SMN2RAB9A
SCHEMBL31259192 0.70 MAPT (0.38) MAPTALDH1A1MT-CO2KMT2APOLB
SCHEMBL9738553 0.68
SCHEMBL5433945 0.67 TSHR (0.40) MAPTALDH1A1
Dimethylcarbate SCHEMBL10504107 0.67 MT-CO2 (0.35) MAPTALDH1A1MT-CO2
SCHEMBL28534498 0.67 HDAC2 (0.55) ALDH1A1RAB9A
SCHEMBL1374641 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4493533-A1 BIOCATALYTIC SYNTHESIS OF (1S,3S)-3-HYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID COMPOUNDS Bristol-Myers Squibb Company (US) 2025-01-22 EP disclosed
CN-118871414-A Biocatalytic synthesis of (1S, 3S) -3-hydroxycyclohexane-1-carboxylic acid compounds 百时美施贵宝公司 2024-10-29 CN disclosed
WO-2023178061-A1 BIOCATALYTIC SYNTHESIS OF (1S,3S)-3-HYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2023-09-21 WO disclosed