SCHEMBL255778

SCHEMBL255778

COc1ccc2c(c1O[C@H]1CCNC1)CCC2

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 7/20 0.43
SLC6A2 P23975 7/20 0.43
PDE4B Q07343 1/20 0.42
PDE4A P27815 2/20 0.40
HTR2C P28335 7/20 0.40
HTR2B P41595 7/20 0.40
HTR2A P28223 1/20 0.40
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29301888 1.00 HTR1A (0.43) HTR1ASLC6A2PDE4BPDE4AHTR2C
Hydrochloric Acid SCHEMBL6969650 0.99 HTR1A (0.42) HTR1ASLC6A2PDE4BPDE4AHTR2C
Hydrochloric Acid SCHEMBL6963984 0.99 HTR1A (0.42) HTR1ASLC6A2PDE4BPDE4AHTR2C
Hydrochloric Acid SCHEMBL6959004 0.99 HTR1A (0.42) HTR1ASLC6A2PDE4BPDE4AHTR2C
SCHEMBL10199778 0.89 PDE4A (0.40) HTR1ASLC6A2PDE4AHTR2CHTR2B
Hydrochloric Acid SCHEMBL6954720 0.88 PDE4A (0.40) PDE4AHTR2CHTR2BHTR2ASLC6A4
SCHEMBL8554408 0.86 PDE4A (0.40) PDE4AHTR2CHTR2BHTR2ASLC6A4
Hydrochloric Acid SCHEMBL6964728 0.85 ADRA1D (0.40) PDE4AHTR2CHTR2BHTR2ASLC6A4
SCHEMBL11626560 0.75 ALDH1A1 (0.49) HTR2CHTR2BHTR2A
SCHEMBL8441694 0.73 ESR1 (0.39) HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220146492-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2022-05-12 US claimed
EP-3953000-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY Shine, Ian Basil (US) 2022-02-16 EP claimed
EP-2983473-A2 PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF ALS Mountain Llc (US) 2016-02-17 EP claimed
WO-2014195695-A1 THERAPEUTIC COMBINATIONS CAMBRIDGE ENTERPRISE LIMITED (GB) 2014-12-11 WO claimed
US-20140350064-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF ALS MOUNTAIN LLC 2014-11-27 US claimed
WO-2014144130-A2 PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF ALS MOUNTAIN LLC (US) 2014-09-18 WO claimed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US claimed
EP-4525833-A2 VETERINARY PHARMACEUTICAL FORMULATIONS Increvet, Inc. (US) 2025-03-26 EP disclosed
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS INCREVET, INC. 2023-11-23 US disclosed
WO-2023225492-A2 VETERINARY PHARMACEUTICAL FORMULATIONS INCREVET, INC. (US) 2023-11-23 WO disclosed
WO-2023220930-A1 VETERINARY PHARMACEUTICAL FORMULATIONS CROSS-REFERENCES TO RELATED APPLICATIONS INCREVET, INC. (US) 2023-11-23 WO disclosed
US-20220249440-A1 MUSCLE REGENERATION PROMOTER SATO PHARMACEUTICAL CO., LTD. (JP) 2022-08-11 US disclosed
US-20220146492-A1 CELL MEMBRANE PERMEABILITY RESTORING THERAPY SHINE IAN BASIL (US) 2022-05-12 US disclosed
US-20100266504-A1 CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-21 US disclosed
US-20090131402-A1 Fused heterocyclic compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED 2009-05-21 US disclosed
US-20090131402-A1 Fused heterocyclic compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED 2009-05-21 US disclosed
EP-2018863-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-01-28 EP disclosed
US-20070274913-A1 Preventives/Remedies for Stress Urinary Incontinence and Method of Screening the Same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-11-29 US disclosed
US-20070274913-A1 Preventives/Remedies for Stress Urinary Incontinence and Method of Screening the Same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-11-29 US disclosed
EP-1792629-A1 PREVENTIVES/REMEDIES FOR STRESS URINARY INCONTINENCE AND METHOD OF SCREENING THE SAME Takeda Pharmaceutical Company Limited (JP) 2007-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131402-A1 Fused heterocyclic compound and use thereof HTR2C, HTR3C, HTR3B HTR1A 9/4885SLC6A2 36/4885PDE4B 778/4885
US-20220249440-A1 MUSCLE REGENERATION PROMOTER MUSK, MYLK2, MYH2 HTR1A 20/4885SLC6A2 430/4885PDE4B 191/4885
US-20230372374-A1 VETERINARY PHARMACEUTICAL FORMULATIONS SLC5A2, SLC5A1, SLC2A8 HTR1A 882/4885SLC6A2 221/4885PDE4B 470/4885
US-20100266504-A1 CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF HTR2C, HTR5A, HTR3C HTR1A 11/4885SLC6A2 158/4885PDE4B 846/4885
US-20070274913-A1 Preventives/Remedies for Stress Urinary Incontinence and Method of Screening the Same ADRA2C, HTR2C, HTR3A HTR1A 9/4885SLC6A2 57/4885PDE4B 147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.