Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589522 | 0.93 | EPHX2 (0.56) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL2585532 | 0.88 | HIF1A (0.52) | RAB9ASMN1; SMN2NPC1KMT2AALDH1A1 | |
| SCHEMBL1475037 | 0.85 | HIF1A (0.62) | RAB9ASMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL2582407 | 0.84 | P2RX7 (0.54) | CYP1A2CYP2C19HIF1A | |
| SCHEMBL2585139 | 0.81 | LMNA (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL2581683 | 0.80 | ECE1 (0.48) | RAB9ASMN1; SMN2KMT2AMAPK1HIF1A | |
| SCHEMBL2585927 | 0.79 | WNT1 (0.46) | SMN1; SMN2ALDH1A1CYP1A2MAPK1HSD17B10 | |
| SCHEMBL2586922 | 0.78 | HIF1A (0.72) | RAB9ANPC1ALDH1A1HIF1A | |
| SCHEMBL2586722 | 0.76 | WNT1 (0.49) | RAB9ASMN1; SMN2NPC1ALDH1A1CYP1A2 | |
| SCHEMBL2581684 | 0.75 | PIN1 (0.46) | RAB9ANPC1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |