Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2586922 | 0.86 | HIF1A (0.72) | HIF1ARAB9ANPC1ALDH1A1NPSR1 | |
| SCHEMBL2582356 | 0.74 | KMT2A (0.46) | HIF1ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2576273 | 0.72 | ALDH1A1 (0.48) | HIF1ARAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL2585927 | 0.72 | WNT1 (0.46) | HIF1ASMN1; SMN2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2590019 | 0.71 | HIF1A (0.68) | HIF1ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2585532 | 0.70 | HIF1A (0.52) | HIF1ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2589092 | 0.70 | HIF1A (0.43) | HIF1ANAMPT | |
| SCHEMBL28970683 | 0.70 | HIF1A (1.00) | HIF1A | |
| SCHEMBL1970224 | 0.69 | GAA (0.81) | RAB9ASMN1; SMN2NPC1KDM4EALDH1A1 | |
| SCHEMBL2585707 | 0.68 | RAB9A (0.54) | HIF1ARAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |