Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 16/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581794 | 0.86 | HIF1A (0.60) | HIF1AHTTNPC1ALDH1A1RAB9A | |
| SCHEMBL28970683 | 0.84 | HIF1A (1.00) | HIF1AROCK1 | |
| SCHEMBL2585532 | 0.80 | HIF1A (0.52) | HIF1AROCK1NPC1ALDH1A1LMNA | |
| SCHEMBL2585707 | 0.78 | RAB9A (0.54) | HIF1ANPC1ALDH1A1RAB9A | |
| SCHEMBL2589522 | 0.76 | EPHX2 (0.56) | HIF1AHTTNPC1ALDH1A1RAB9A | |
| SCHEMBL2585139 | 0.74 | LMNA (0.58) | HTTALDH1A1LMNA | |
| SCHEMBL2582356 | 0.73 | KMT2A (0.46) | HIF1AHTTNPC1ALDH1A1LMNA | |
| SCHEMBL2590019 | 0.73 | HIF1A (0.68) | HIF1ANPC1ALDH1A1LMNARAB9A | |
| SCHEMBL2589092 | 0.72 | HIF1A (0.43) | HIF1ANAMPT | |
| SCHEMBL2576273 | 0.71 | ALDH1A1 (0.48) | HIF1ANPC1ALDH1A1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |