Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577721 | 0.83 | ALDH1A1 (0.50) | MMP1MMP2MMP9MMP12MEN1 | |
| SCHEMBL6652016 | 0.81 | HTR2A (0.55) | MMP1MMP2MMP9MMP12MEN1 | |
| SCHEMBL697595 | 0.77 | KMT2A (0.60) | MEN1KMT2AHTTGFERHSD17B10 | |
| SCHEMBL9407475 | 0.77 | LMNA (0.50) | MMP1MMP2MMP9MMP12MEN1 | |
| SCHEMBL322125 | 0.76 | MAPT (0.44) | MEN1KMT2AHTTGFERHSD17B10 | |
| SCHEMBL1581585 | 0.74 | ALOX15 (0.57) | MEN1KMT2AHSD17B10MAPTTDP1 | |
| SCHEMBL8646552 | 0.74 | THRB (0.47) | MEN1KMT2AHSD17B10MAPTTDP1 | |
| SCHEMBL10025073 | 0.74 | MAPT (0.46) | MEN1KMT2AHTTGFERHSD17B10 | |
| SCHEMBL21980920 | 0.73 | KMT2A (0.54) | MMP1MMP2MMP9MMP12MEN1 | |
| SCHEMBL6901171 | 0.73 | MMP1 (0.53) | MMP1MMP2MMP9MMP12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067456-B2 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCPs) | AETERNA ZENTARIS GMBH (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20080280965-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCPs) | KLAUS PAULINI, ET AL. | 2008-11-13 | — | — | US | disclosed |
| US-7375127-B2 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | AE ZENTARIS GMBH (DE) | 2008-05-20 | — | — | US | disclosed |
| US-20060014818-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014818-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | GPR88, GPR34, GPR35 | MMP1 3011/4885MMP2 2616/4885MMP9 3731/4885 |
| US-20080280965-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCPs) | GPR35, GPR88, GPBAR1 | MMP1 2931/4885MMP2 3054/4885MMP9 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.