Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581145 | 0.80 | TSHR (0.50) | P2RX7ROCK2 | |
| SCHEMBL2585532 | 0.76 | HIF1A (0.52) | GSK3BKMT2AROCK2HIF1A | |
| SCHEMBL2584587 | 0.76 | ROCK2 (0.48) | MEN1KMT2AP2RX7ROCK2DGAT2 | |
| SCHEMBL2582356 | 0.72 | KMT2A (0.46) | GSK3BMEN1KMT2AHIF1A | |
| SCHEMBL6543656 | 0.72 | THRB (0.55) | GSK3BMEN1KMT2A | |
| SCHEMBL2589092 | 0.72 | HIF1A (0.43) | GSK3BROCK2HIF1A | |
| SCHEMBL2585927 | 0.71 | WNT1 (0.46) | HIF1A | |
| SCHEMBL2576273 | 0.71 | ALDH1A1 (0.48) | MEN1KMT2AHIF1A | |
| SCHEMBL5083302 | 0.71 | CXCR4 (0.60) | GSK3BMEN1KMT2AP2RX7ROCK2 | |
| SCHEMBL2585707 | 0.70 | RAB9A (0.54) | MEN1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |