SCHEMBL259016

SCHEMBL259016

CCCCCC(N)(N)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FDPS P14324 2/20 0.48
SMPD1 P17405 4/20 0.47
AKR1B1 P15121 1/20 0.42
CES2 O00748 1/20 0.42
ARG1 P05089 1/20 0.41
ARG2 P78540 1/20 0.41
PPARG P37231 4/20 0.41
PPARD Q03181 4/20 0.41
PPARA Q07869 4/20 0.41
TSHR P16473 3/20 0.41
GPR84 Q9NQS5 3/20 0.41
HDAC11 Q96DB2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
SLC22A6 Q4U2R8 1/20 0.41
SLC22A8 Q8TCC7 1/20 0.41
TLR2 O60603 1/20 0.41
MEN1 O00255 1/20 0.41
ESR1 P03372 1/20 0.41
FABP4 P15090 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31018949 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL14931594 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL20599006 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL287722 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL4421180 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL1027737 0.98 SMPD1 (0.50) FDPSSMPD1CES2PPARGPPARD
SCHEMBL288685 0.93 FDPS (0.46) FDPSSMPD1AKR1B1ARG1ARG2
Propionic Acid SCHEMBL7632408 0.92 SMPD1 (0.46) FDPSSMPD1PPARGPPARDPPARA
Hydrochloric Acid SCHEMBL28391923 0.91 FDPS (0.45) FDPSSMPD1AKR1B1ARG1ARG2
Hydrochloric Acid SCHEMBL27328297 0.91 FDPS (0.45) FDPSSMPD1AKR1B1ARG1ARG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118497101-B Recombinant escherichia coli without auxotrophy and plasmid for producing L-homoserine and application thereof 中国科学院微生物研究所 2024-10-25 CN claimed
CN-118685334-A Engineering bacterium for producing L-isoleucine and construction method and application thereof 中国科学院微生物研究所 2024-09-24 CN claimed
CN-118497101-A Recombinant escherichia coli without auxotrophy and plasmid for producing L-homoserine and application thereof 中国科学院微生物研究所 2024-08-16 CN claimed
CN-118388598-A Labeling precursor, probe, preparation method and application thereof 苏州大学附属第一医院 2024-07-26 CN claimed
CN-113956992-B L-homoserine tolerant escherichia coli and application thereof 中国科学院微生物研究所 2023-09-01 CN claimed
WO-2022257757-A1 DAPB GENE-BASED POLYNUCLEOTIDE HAVING PROMOTER ACTIVITY AND USE THEREOF 中国科学院天津工业生物技术研究所 2022-12-15 WO claimed
CN-112725251-B Engineering bacterium for producing spermidine 江南大学 2022-07-22 CN claimed
CN-113122487-B Recombinant bacterium for high yield of L-homoserine, and preparation method and application thereof 中国科学院微生物研究所 2022-05-24 CN claimed
EP-2499148-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS Polyphor Ag (CH) 2012-09-19 EP claimed
US-8192976-B2 Biological synthesis of difunctional alkanes from carbohydrate feedstocks CELEXION, LLC (US) 2012-06-05 US claimed
US-8133704-B2 Biological synthesis of difunctional alkanes from carbohydrate feedstocks CELEXION, LLC (US) 2012-03-13 US claimed
CN-102317464-A From alpha-ketoacid biosynthesizing difunctionality alkane CELEXION LLC 2012-01-11 CN claimed
US-20110171696-A1 Biological Synthesis of Difunctional Alkanes from Carbohydrate Feedstocks CELEXION, LLC (US) 2011-07-14 US claimed
WO-2011014973-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2011-02-10 WO claimed
EP-1077692-B1 AMINO ACID STABILIZED GABAPENTIN AND PREGABALIN PREPARATIONS AND PROCESS FOR PREPARING THE SAME WARNER LAMBERT CO (US) 2004-07-28 EP claimed
EP-1077692-A1 AMINO ACID STABILIZED GABAPENTIN AND PREGABALIN PREPARATIONS AND PROCESS FOR PREPARING THE SAME Warner-Lambert Company LLC (US) 2001-02-28 EP claimed
WO-1999059573-A9 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER LAMBERT CO (US) 2000-05-04 WO claimed
WO-1999059573-A1 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER-LAMBERT COMPANY (US) 1999-11-25 WO claimed
US-5352453-A Acidic ph BOEHRINGER MANNHEIM GMBH (DE) 1994-10-04 US claimed
US-20250340587-A1 INSOLUBLE SUPPORT FOR SOLID PHASE SYNTHESIS POLYPEPTIDE LABORATORIES HOLDING PPL AB (SE) 2025-11-06 US disclosed
US-12383522-B2 Baclofen formulations and methods of minimizing patient exposure to metabolite variations AMNEAL PHARMACEUTICALS LLC (US) 2025-08-12 US disclosed
US-20250129126-A1 LONG-LASTING HEPATITIS VIRUS ENTRY INHIBITOR Chengdu AODA Biotechnology Co., Ltd (CN) 2025-04-24 US disclosed
EP-4532509-A1 INSOLUBLE SUPPORT FOR SOLID PHASE SYNTHESIS Polypeptide Laboratories Holding (PPL) AB (SE) 2025-04-09 EP disclosed
WO-2024255806-A1 PREPARATION AND USE OF HYDROGEL 粤港澳大湾区精准医学研究院(广州) 2024-12-19 WO disclosed
CN-119144151-A Preparation of hydrogels and uses thereof 粤港澳大湾区精准医学研究院(广州) 2024-12-17 CN disclosed
CN-118497101-B Recombinant escherichia coli without auxotrophy and plasmid for producing L-homoserine and application thereof 中国科学院微生物研究所 2024-10-25 CN disclosed
CN-118685334-A Engineering bacterium for producing L-isoleucine and construction method and application thereof 中国科学院微生物研究所 2024-09-24 CN disclosed
CN-118497101-A Recombinant escherichia coli without auxotrophy and plasmid for producing L-homoserine and application thereof 中国科学院微生物研究所 2024-08-16 CN disclosed
CN-118388598-A Labeling precursor, probe, preparation method and application thereof 苏州大学附属第一医院 2024-07-26 CN disclosed
CN-118286386-A Application of NOD1 agonist in preparation of medicines for treating hepatocellular carcinoma 复旦大学附属中山医院 2024-07-05 CN disclosed
EP-4392071-A1 METHOD OF SYNTHESIZING DENDRIMERIC AMPHIPHILE Kaohsiung Medical University (TW) 2024-07-03 EP disclosed
US-11931328-B2 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives AMNEAL PHARMACEUTICALS LLC (US) 2024-03-19 US disclosed
US-20240082193-A1 BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS AMNEAL PHARMACEUTICALS LLC (US) 2024-03-14 US disclosed
US-11850225-B2 Baclofen formulations and methods of minimizing patient exposure to metabolite variations AMNEAL PHARMACEUTICALS LLC (US) 2023-12-26 US disclosed
WO-2023234837-A1 INSOLUBLE SUPPORT FOR SOLID PHASE SYNTHESIS POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) 2023-12-07 WO disclosed
CN-113956992-B L-homoserine tolerant escherichia coli and application thereof 中国科学院微生物研究所 2023-09-01 CN disclosed
CN-108456669-B Ribosome binding site, recombinant expression plasmid, transformant and application thereof 上海凯赛生物技术股份有限公司 2023-08-08 CN disclosed
CN-108456668-B Ribosome binding site, recombinant expression plasmid, transformant and application thereof 上海凯赛生物技术股份有限公司 2023-08-08 CN disclosed
US-20230218554-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES AMNEAL PHARMACEUTICALS LLC (US) 2023-07-13 US disclosed
EP-3611254-B1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF HEXAMETHYLENEDIAMINE GENOMATICA INC (US) 2023-07-05 EP disclosed
US-11654124-B2 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives AMNEAL PHARMACEUTICALS LLC (US) 2023-05-23 US disclosed
US-20230103372-A1 BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS AMNEAL PHARMACEUTICALS LLC (US) 2023-04-06 US disclosed
WO-2023055457-A1 BACLOFEN-CONTAINING GRANULE FORMULATIONS AND REDUCED PATIENT EXPOSURE TO METABOLITE VARIATIONS AMNEAL PHARMACEUTICALS LLC (US) 2023-04-06 WO disclosed
WO-2023023889-A1 METHOD OF SYNTHESIZING DENDRIMERIC AMPHIPHILE KAOHSIUNG MEDICAL UNIVERSITY (CN) 2023-03-02 WO disclosed
US-11591366-B2 Macrocyclic compounds and methods of preventing or treating pain SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C. (CA) 2023-02-28 US disclosed
WO-2022257757-A1 DAPB GENE-BASED POLYNUCLEOTIDE HAVING PROMOTER ACTIVITY AND USE THEREOF 中国科学院天津工业生物技术研究所 2022-12-15 WO disclosed
US-11491125-B1 Baclofen formulations and methods of minimizing patient exposure to metabolite variations AMNEAL PHARMACEUTICALS LLC (US) 2022-11-08 US disclosed
US-20220308068-A1 BIOMARKER IN OSTEOPOROSIS INTERVENTION THERAPY BY BONE PEPTIDE, SCREENING METHOD AND USE THEREOF Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CN) 2022-09-29 US disclosed
US-20220265588-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES AMNEAL PHARMACEUTICALS LLC (US) 2022-08-25 US disclosed
CN-109790557-B Controlling biofilm dispersion to produce amino acids or amino acid-derived products 上海凯赛生物技术股份有限公司 2022-08-19 CN disclosed
CN-108977373-B Bacillus terracotta cotta HMD9161 and microbial inoculum and application thereof 中国热带农业科学院热带生物技术研究所 2022-06-28 CN disclosed
EP-4003323-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES Saol International Research Ltd. (BM) 2022-06-01 EP disclosed
CN-113122487-B Recombinant bacterium for high yield of L-homoserine, and preparation method and application thereof 中国科学院微生物研究所 2022-05-24 CN disclosed
CN-114450002-A Stable formulations of 4-amino-3-substituted butyric acid derivatives 萨欧国际研究有限公司 2022-05-06 CN disclosed
CN-111662918-B Co-production method of multi-protein system, co-production system of multi-protein system and application 深圳先进技术研究院 2022-04-22 CN disclosed
CN-111621511-B Co-production method of multi-protein system, circulating co-production system of multi-protein system and application 中国科学院深圳先进技术研究院 2022-04-08 CN disclosed
CN-113956992-A L-homoserine-tolerant escherichia coli and application thereof 中国科学院微生物研究所 2022-01-21 CN disclosed
WO-2021237410-A1 CO-PRODUCTION METHOD FOR MULTIPROTEIN SYSTEM, CO-PRODUCTION SYSTEM FOR MULTIPROTEIN SYSTEM AND USE THEREOF 深圳先进技术研究院 2021-12-02 WO disclosed
WO-2021237411-A1 CO-PRODUCTION METHOD FOR MULTI-PROTEIN SYSTEM, CYCLIC CO-PRODUCTION SYSTEM FOR MULTI-PROTEIN SYSTEM, AND USE 中国科学院深圳先进技术研究院 2021-12-02 WO disclosed
CN-106661418-B Adhesive agent 克瑙夫绝缘私人有限公司 2021-07-09 CN disclosed
WO-2021021277-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES SAOL INTERNATIONAL LIMITED (BM) 2021-02-04 WO disclosed
US-10792262-B1 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives SAOL INTERNATIONAL LIMITED (BM) 2020-10-06 US disclosed
CN-111662918-A Co-production method of multi-protein system, co-production system of multi-protein system and application 深圳先进技术研究院 2020-09-15 CN disclosed
CN-111621511-A Co-production method of multi-protein system, circulating co-production system of multi-protein system and application 中国科学院深圳先进技术研究院 2020-09-04 CN disclosed
US-10751312-B1 2020-08-25 US disclosed
US-20180362582-A1 MACROCYCLIC COMPOUNDS AND METHODS OF PREVENTING OR TREATING PAIN UNIVERSITé DE SHERBROOKE (CA) 2018-12-20 US disclosed
CN-104745650-B For the preparation method for the reference state glutamine for improving nutrients in intestine of young pigs 郑州新威营养技术有限公司 2018-02-02 CN disclosed
WO-2017134148-A1 SELECTIVE CELL PENETRATING PEPTIDES STICHTING KATHOLIEKE UNIVERSITEIT (NL) 2017-08-10 WO disclosed
EP-3146010-A1 BINDERS Knauf Insulation, Inc. (US) 2017-03-29 EP disclosed
WO-2015177114-A1 BINDERS KNAUF INSULATION, LLC (US) 2015-11-26 WO disclosed
WO-2012177721-A1 MICROORGANISMS FOR PRODUCING 6-AMINOCAPROIC ACID GENOMATICA, INC. (US) 2012-12-27 WO disclosed
EP-2427476-A1 BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY Polyphor Ag (CH) 2012-03-14 EP disclosed
CN-102317464-A From alpha-ketoacid biosynthesizing difunctionality alkane CELEXION LLC 2012-01-11 CN disclosed
WO-2010127704-A1 BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY POLYPHOR AG (CH) 2010-11-11 WO disclosed
WO-2009078040-A2 COMPOUNDS INDUCING REPERFUSION IN ISCHAEMIC TISSUES DATTA DEBATOSH (IN) 2009-06-25 WO disclosed
US-7309719-B1 Storage stability; gabapentin and pregabalin, and neutral alpha -amino acid WARNER LAMBERT COMPANY, LLC (US) 2007-12-18 US disclosed
EP-1077692-B1 AMINO ACID STABILIZED GABAPENTIN AND PREGABALIN PREPARATIONS AND PROCESS FOR PREPARING THE SAME WARNER LAMBERT CO (US) 2004-07-28 EP disclosed
EP-1261611-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-12-04 EP disclosed
EP-1196436-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-04-17 EP disclosed
WO-2001064678-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-09-07 WO disclosed
EP-1077692-A1 AMINO ACID STABILIZED GABAPENTIN AND PREGABALIN PREPARATIONS AND PROCESS FOR PREPARING THE SAME Warner-Lambert Company LLC (US) 2001-02-28 EP disclosed
WO-2001002424-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE DU PONT PHARMACEUTICALS COMPANY (US) 2001-01-11 WO disclosed
WO-1999059573-A9 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER LAMBERT CO (US) 2000-05-04 WO disclosed
WO-1999059573-A1 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER-LAMBERT COMPANY (US) 1999-11-25 WO disclosed
WO-1999059573-A1 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER-LAMBERT COMPANY (US) 1999-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10792262-B1 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives ABAT, GABRA6, BCAT2 FDPS 901/4885SMPD1 2389/4885AKR1B1 2981/4885
US-11654124-B2 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives GABRA6, GABBR1, GABBR2 FDPS 1981/4885SMPD1 3541/4885AKR1B1 1372/4885
US-20240082193-A1 BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS GABRB1, GABRB2, GABBR1 FDPS 3340/4885SMPD1 982/4885AKR1B1 203/4885
US-20250340587-A1 INSOLUBLE SUPPORT FOR SOLID PHASE SYNTHESIS SSU72, CPSF6, IDUA FDPS 986/4885SMPD1 3116/4885AKR1B1 3412/4885
US-20220265588-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES GABRA6, GABBR1, GABBR2 FDPS 1981/4885SMPD1 3541/4885AKR1B1 1372/4885
US-11591366-B2 Macrocyclic compounds and methods of preventing or treating pain COX15, ACHE, TRPV1 FDPS 1257/4885SMPD1 3044/4885AKR1B1 398/4885
US-20180362582-A1 MACROCYCLIC COMPOUNDS AND METHODS OF PREVENTING OR TREATING PAIN COX15, ACHE, TRPV1 FDPS 1257/4885SMPD1 3044/4885AKR1B1 398/4885
US-12383522-B2 Baclofen formulations and methods of minimizing patient exposure to metabolite variations GABRB1, GABRB2, GABBR1 FDPS 3340/4885SMPD1 982/4885AKR1B1 203/4885
US-11931328-B2 Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives GABRA6, GABBR1, GABBR2 FDPS 1981/4885SMPD1 3541/4885AKR1B1 1372/4885
US-11491125-B1 Baclofen formulations and methods of minimizing patient exposure to metabolite variations GABRB1, GABRB2, GABBR1 FDPS 3340/4885SMPD1 982/4885AKR1B1 203/4885
US-11850225-B2 Baclofen formulations and methods of minimizing patient exposure to metabolite variations GABRB1, GABRB2, GABBR1 FDPS 3364/4885SMPD1 1069/4885AKR1B1 208/4885
US-20230218554-A1 STABILIZED FORMULATIONS OF 4-AMINO-3-SUBSTITUTED BUTANOIC ACID DERIVATIVES GABRA6, GABBR1, GABBR2 FDPS 1981/4885SMPD1 3541/4885AKR1B1 1372/4885
US-20230103372-A1 BACLOFEN FORMULATIONS AND METHODS OF MINIMIZING PATIENT EXPOSURE TO METABOLITE VARIATIONS GABRB1, GABRB2, GABBR1 FDPS 3364/4885SMPD1 1069/4885AKR1B1 208/4885
US-10751312-B1 LIPA, CEL, GANC FDPS 781/4885SMPD1 109/4885AKR1B1 2662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.