SCHEMBL259724

SCHEMBL259724

C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC(F)[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 10/20 0.70
NR3C1 P04150 5/20 0.70
SERPINA6 P08185 4/20 0.70
LMNA P02545 3/20 0.70
TSHR P16473 3/20 0.70
SHBG P04278 3/20 0.70
CYP3A4 P08684 3/20 0.70
SMN1; SMN2 Q16637 3/20 0.70
ALDH1A1 P00352 2/20 0.70
PMP22 Q01453 2/20 0.70
CYP2D6 P10635 1/20 0.70
KCNA1 Q09470 1/20 0.70
SLC47A1 Q96FL8 1/20 0.70
HIF1A Q16665 5/20 0.66
KMT2A Q03164 4/20 0.66
MEN1 O00255 2/20 0.66
PGR P06401 2/20 0.66
SLC29A1 Q99808 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
CYP2C19 P33261 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8217259 0.90 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL28023466 0.90 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL342689 0.90 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL4971575 0.90 HSD17B10 (0.71) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL5082089 0.89 HSD17B10 (0.70) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL582662 0.88 FNTA (0.72) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL28941264 0.88 HSD17B10 (0.69) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL27607895 0.88 HSD17B10 (0.69) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL30483614 0.87 HSD17B10 (0.68) HSD17B10NR3C1SERPINA6LMNATSHR
SCHEMBL21875771 0.85 HSD17B10 (0.66) HSD17B10NR3C1SERPINA6LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1289 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250222117-A1 COMPOUND COMPRISING RALTITREXED OR 5-MTHF LINKED TO A THERAPEUTIC AGENT, COMPOSITION, AND METHOD OF USE PURDUE RESEARCH FOUNDATION 2025-07-10 US claimed
EP-4463149-A2 COMPOUND COMPRISING RALTITREXED OR 5-MTHF LINKED TO A THERAPEUTIC AGENT, COMPOSITION, AND METHOD OF USE Purdue Research Foundation (US) 2024-11-20 EP claimed
US-12070442-B2 Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease SURFACE OPHTHALMICS, INC. (US) 2024-08-27 US claimed
US-20230331767-A1 TARGETED STEROID COMPOUNDS PURDUE RESEARCH FOUNDATION 2023-10-19 US claimed
US-20230277557-A1 PHARMACEUTICAL KITS AND THEIR USE FOR TREATING DRY EYE DISEASE SURFACE OPHTHALMICS INC (US) 2023-09-07 US claimed
EP-4214183-A1 PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF Essa Pharma, Inc. (CA) 2023-07-26 EP claimed
WO-2023137403-A2 COMPOUND COMPRISING RALTITREXED OR 5-MTHF LINKED TO A THERAPEUTIC AGENT, COMPOSITION, AND METHOD OF USE PURDUE RESEARCH FOUNDATION (US) 2023-07-20 WO claimed
US-20230192717-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY CASE WESTERN RESERVE UNIVERSITY 2023-06-22 US claimed
EP-4153299-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY Rodeo Therapeutics Corporation (US) 2023-03-29 EP claimed
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY RODEO THERAPEUTICS CORPORATION 2023-02-09 US claimed
US-5192528-A Encapsulated in liposomes, aerosols LIPOSOME TECHNOLOGY, INC. (US) 1993-03-09 US claimed
US-5049389-A Non-phospholipd lipid, delivery by inhalation LIPOSOME TECHNOLOGY, INC. (US) 1991-09-17 US claimed
US-5043165-A Cholesterol and salt; antiallergens, antiinflammatory agents, skin disorders LIPOSOME TECHNOLOGY, INC. (US) 1991-08-27 US claimed
US-4957744-A COSMETICS, PHARMACEUTICALS, PLASTICS FOR SANITARY AND SURGICAL ARTICLES FIDIA, S.P.A. (IT) 1990-09-18 US claimed
US-4954345-A CORTICOSTEROIDS AND-OR TRIHYDROXYANTHRACENES ROHM PHARMA GMBH (DE) 1990-09-04 US claimed
WO-1990006775-A1 A NOVEL NONPHOSPHOLIPID LIPOSOME COMPOSITION FOR SUSTAINED RELEASE OF DRUGS LIPOSOME TECHNOLOGY, INC. (US) 1990-06-28 WO claimed
US-4906476-A Novel liposome composition for sustained release of steroidal drugs in lungs LIPOSOME TECHNOLOGY, INC. 1990-03-06 US claimed
US-4851521-A Esters of hyaluronic acid FIDIA, S.P.A. (IT) 1989-07-25 US claimed
EP-0265116-A2 Cross-linked esters of hyaluronic acid FIDIA S.p.A. (IT) 1988-04-27 EP claimed
EP-0216453-A2 Esters of hyaluronic acid and their salts. FIDIA S.p.A. (IT) 1987-04-01 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230331767-A1 TARGETED STEROID COMPOUNDS CYP11B2, FOLR2, CYP11B1 HSD17B10 131/4885NR3C1 16/4885SERPINA6 24/4885
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS HSD17B10 21/4885NR3C1 1540/4885SERPINA6 1375/4885
US-20250222117-A1 COMPOUND COMPRISING RALTITREXED OR 5-MTHF LINKED TO A THERAPEUTIC AGENT, COMPOSITION, AND METHOD OF USE MTHFD1, MTHFD2, DHFR HSD17B10 1355/4885NR3C1 1515/4885SERPINA6 1739/4885
US-20230192717-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS HSD17B10 21/4885NR3C1 1540/4885SERPINA6 1375/4885
US-12070442-B2 Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease EYA3, HSD3B1, HMGCR HSD17B10 749/4885NR3C1 31/4885SERPINA6 25/4885
US-20230277557-A1 PHARMACEUTICAL KITS AND THEIR USE FOR TREATING DRY EYE DISEASE TSLP, SERPINA6, IL5 HSD17B10 1879/4885NR3C1 24/4885SERPINA6 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.