Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.86 |
| ▸ | MAPT | P10636 | 9/20 | 0.86 |
| ▸ | BACE1 | P56817 | 5/20 | 0.86 |
| ▸ | MMP9 | P14780 | 4/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.86 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.86 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.86 |
| ▸ | MAOA | P21397 | 2/20 | 0.86 |
| ▸ | MAOB | P27338 | 2/20 | 0.86 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.86 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.86 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.86 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.86 |
| ▸ | STAT3 | P40763 | 2/20 | 0.86 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13469154 | 1.00 | APP (0.86) | APPMAPTBACE1MMP9NFKB1 | |
| SCHEMBL3211934 | 0.93 | APP (0.84) | APPMAPTBACE1MMP9NFKB1 | |
| SCHEMBL3211947 | 0.93 | APP (0.84) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL17629819 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL8440 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL8336603 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL6901740 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL2804734 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL250984 | 0.93 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| SCHEMBL14495458 | 0.93 | NFE2L2 (0.77) | APPMAPTBACE1MMP9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192786-A1 | STAT3 INHIBITION FOR TREATMENT AND PREVENTION OF HUMAN CORONAVIRUS INFECTION | GLG PHARMA LLC (US) | 2023-06-22 | — | — | US | disclosed |
| EP-3090748-B1 | COMPOSITIONS COMPRISING NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS | SPRING BANK PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017194590-A1 | PROCESS FOR THE MANUFACTURE OF HYDROXY-SUBSTITUTED AROMATIC COMPOUNDS | BASF SE (DE) | 2017-11-16 | — | — | WO | disclosed |
| US-9757407-B2 | Treatment of viral infections by modulation of host cell metabolic pathways | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160346309-A1 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS | UNIV PRINCETON (US) | 2016-12-01 | — | — | US | disclosed |
| US-9029413-B2 | Treatment of viral infections by modulation of host cell metabolic pathways | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-20130065850-A1 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2013-03-14 | — | — | US | disclosed |
| US-8158677-B2 | Treatment of viral infections by modulation of host cell metabolic pathways | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2012-04-17 | — | — | US | disclosed |
| US-20110064720-A1 | Dietary Supplement Compositions and Methods of Making and Using the Same | AMATO DANIEL MOSES | 2011-03-17 | — | — | US | disclosed |
| US-20110064712-A1 | Dietary Supplement Compositions and Methods of Making and Using the Same | AMATO DANIEL MOSES | 2011-03-17 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| US-20090239830-A1 | Treatment of viral infections by modulation of host cell metabolic pathways | KADMON CORPORATION, LLC | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239830-A1 | Treatment of viral infections by modulation of host cell metabolic pathways | GOT2, MAVS, ME3 | APP 3745/4885MAPT 2526/4885BACE1 2224/4885 |
| US-20110064720-A1 | Dietary Supplement Compositions and Methods of Making and Using the Same | SLC5A6, PNLIP, LIPC | APP 3242/4885MAPT 3584/4885BACE1 3892/4885 |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | BHMT2, HMOX1, DEPTOR | APP 694/4885MAPT 735/4885BACE1 1739/4885 |
| US-20160346309-A1 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS | GOT2, MAVS, ME3 | APP 3745/4885MAPT 2526/4885BACE1 2224/4885 |
| US-20110064712-A1 | Dietary Supplement Compositions and Methods of Making and Using the Same | SLC5A6, PNLIP, LIPC | APP 3242/4885MAPT 3584/4885BACE1 3892/4885 |
| US-20130065850-A1 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS | GOT2, MAVS, ME3 | APP 3745/4885MAPT 2526/4885BACE1 2224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.