Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330291 | 1.00 | KDM1A (0.47) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL523614 | 0.84 | NPSR1 (0.54) | NPSR1CXCR4ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL23895431 | 0.80 | KDM1A (0.45) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL8739934 | 0.80 | PARP1 (0.46) | KDM1AMAOAMAOBMBOAT4PARP1 | |
| SCHEMBL5338175 | 0.79 | KDM1A (0.44) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL2602354 | 0.77 | MAOA (0.43) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL30275482 | 0.77 | KDM1A (0.43) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL7333040 | 0.77 | CXCR4 (0.52) | NPSR1CXCR4PARP1KDM4ECYP3A4 | |
| SCHEMBL2476858 | 0.77 | SMN1; SMN2 (0.53) | KDM1AMAOAMAOBNPSR1MBOAT4 | |
| SCHEMBL29791992 | 0.77 | SMN1; SMN2 (0.53) | KDM1AMAOAMAOBNPSR1MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103570688-A | 2,5-diaminomethylpyrazine compounds, drug compositions, preparation method and use thereof | SHANGHAI INST MATERIA MEDICA | 2014-02-12 | — | — | CN | claimed |
| EP-4619406-A1 | TRICYCLIC COMPOUNDS | Schrödinger, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2025076285-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | DELPHIA THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| WO-2025042408-A1 | METHODS OF TREATING CANCER | SCHRÖDINGER, INC. (US) | 2025-02-27 | — | — | WO | disclosed |
| WO-2024107393-A1 | TRICYCLIC COMPOUNDS | SCHRÖDINGER, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
| EP-2470012-B1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2014-11-05 | — | — | EP | disclosed |
| CN-103570688-A | 2,5-diaminomethylpyrazine compounds, drug compositions, preparation method and use thereof | SHANGHAI INST MATERIA MEDICA | 2014-02-12 | — | — | CN | disclosed |
| US-8604038-B2 | Pyrrolidine derived beta 3 adrenergic receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-12-10 | — | — | US | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | PROSIDION LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | PROSIDION LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | PROSIDION LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1838698-A1 | PYRIMIDINE DERIVATIVES AS GPCR AGONISTS | Prosidion Limited (GB) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006070208-A1 | PYRIDINE, PYRIMIDINE AND PYRAZINE DERIVATIVES AS GPCR AGONISTS | PROSIDION LTD. (GB) | 2006-07-06 | — | — | WO | disclosed |
| US-7022724-B2 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A α5 receptor subunit ligands | MERCK SHARP & DOHME LTD. (GB) | 2006-04-04 | — | — | US | disclosed |
| US-20040058970-A1 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058970-A1 | Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands | GABRA5, GABRA1, GABRB1 | KDM1A 2965/4885MAOA 593/4885MAOB 1048/4885 |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | GPR119, GPR52, GPR65 | KDM1A 3675/4885MAOA 2234/4885MAOB 1296/4885 |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | TPM3, MUSK, TPM4 | KDM1A 2671/4885MAOA 955/4885MAOB 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.