Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198461 | 1.00 | NPSR1 (0.44) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL13225608 | 1.00 | NPSR1 (0.44) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL5970440 | 0.93 | TPSAB1 (0.44) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL17369157 | 0.89 | NPSR1 (0.45) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL12257304 | 0.88 | TPSAB1 (0.40) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL17369164 | 0.86 | SYK (0.46) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL14744316 | 0.86 | TPSAB1 (0.43) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL14743381 | 0.85 | TPSAB1 (0.43) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL23760112 | 0.84 | TPSAB1 (0.46) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL12873853 | 0.84 | L3MBTL1 (0.44) | NPSR1TPSAB1TPSD1TPSG1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556119-B2 | Process for preparing desmosine, isodesmosine, and derivatives thereof | SOPHIA SCHOOL CORPORATION (JP) | 2017-01-31 | — | — | US | disclosed |
| US-20150376127-A1 | PROCESS FOR PREPARING DESMOSINE, ISODESMOSINE, AND DERIVATIVES THEREOF | SOPHIA SCHOOL CORPORATION (JP) | 2015-12-31 | — | — | US | disclosed |
| US-8906887-B2 | C7-fluoro substituted tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8088368-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100310512-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. | 2010-12-09 | — | — | US | disclosed |
| US-7745427-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| US-7732438-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20100113419-A1 | CGRP RECEPTOR ANTAGONISTS | BURGEY CHRISTOPHER S | 2010-05-06 | — | — | US | disclosed |
| US-20100105671-A1 | C7-fluoro substituted tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. | 2010-04-29 | — | — | US | disclosed |
| US-20100093811-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-04-15 | — | — | US | disclosed |
| US-7534784-B2 | ligands for Calcitonin gene related peptide; azepinone ligands; migranes; N-[5-(2,3-Difluorophenyl)-1-(2-methoxyethyl)-2-oxopiperidin-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | MERCK + CO., INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-7452903-B2 | CGRP receptor antagonists | MERCK & CO., INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-20080280857-A1 | CGRP receptor antagonists | MERCK SHARP & DOHME LLC | 2008-11-13 | — | — | US | disclosed |
| US-7390798-B2 | Carboxamide spirolactam CGRP receptor antagonists | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20080113966-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2008-05-15 | — | — | US | disclosed |
| US-20080090806-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2008-04-17 | — | — | US | disclosed |
| US-20070293470-A1 | Carboxamide Spirolactam Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2007-12-20 | — | — | US | disclosed |
| US-20070287697-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2007-12-13 | — | — | US | disclosed |
| US-20070225272-A1 | CGRP receptor antagonists | MERCK SHARP & DOHME LLC | 2007-09-27 | — | — | US | disclosed |
| US-7235545-B2 | CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093811-A1 | HIV PROTEASE INHIBITORS | PRSS1, FURIN, SERPINB1 | NPSR1 1140/4885TPSAB1 110/4885TPSD1 393/4885 |
| US-20070293470-A1 | Carboxamide Spirolactam Cgrp Receptor Antagonists | BDKRB1, CALCRL, BDKRB2 | NPSR1 133/4885TPSAB1 153/4885TPSD1 576/4885 |
| US-20080090806-A1 | Cgrp Receptor Antagonists | CCKBR, BDKRB1, BDKRB2 | NPSR1 63/4885TPSAB1 117/4885TPSD1 242/4885 |
| US-20080113966-A1 | Cgrp Receptor Antagonists | BDKRB1, BDKRB2, CCKBR | NPSR1 57/4885TPSAB1 142/4885TPSD1 225/4885 |
| US-20100105671-A1 | C7-fluoro substituted tetracycline compounds | F7, TUBA1C, TUBA4A | NPSR1 4173/4885TPSAB1 2613/4885TPSD1 2915/4885 |
| US-20150376127-A1 | PROCESS FOR PREPARING DESMOSINE, ISODESMOSINE, AND DERIVATIVES THEREOF | SI, SMS, SRM | NPSR1 741/4885TPSAB1 566/4885TPSD1 280/4885 |
| US-20070225272-A1 | CGRP receptor antagonists | CCKBR, BDKRB1, BDKRB2 | NPSR1 60/4885TPSAB1 151/4885TPSD1 285/4885 |
| US-20100113419-A1 | CGRP RECEPTOR ANTAGONISTS | BDKRB1, CCKBR, BDKRB2 | NPSR1 46/4885TPSAB1 123/4885TPSD1 274/4885 |
| US-20100310512-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | NPSR1 4462/4885TPSAB1 4100/4885TPSD1 4219/4885 |
| US-20070287697-A1 | Cgrp Receptor Antagonists | BDKRB1, BDKRB2, CCKBR | NPSR1 47/4885TPSAB1 127/4885TPSD1 340/4885 |
| US-20080280857-A1 | CGRP receptor antagonists | CCKBR, BDKRB1, BDKRB2 | NPSR1 60/4885TPSAB1 151/4885TPSD1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.