Sugi Predict

Sugi Predict / Compounds / SCHEMBL2726850

SCHEMBL2726850

SCHEMBL2726850

CCc1ccccc1C(=O)Nc1ccccn1

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.65
▸ KMT2A Q03164 4/20 0.65
▸ KDM4E B2RXH2 1/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.65
▸ NPC1 O15118 7/20 0.62
▸ RAB9A P51151 7/20 0.62
▸ GAA P10253 2/20 0.62
▸ TP53 P04637 1/20 0.62
▸ SMN1; SMN2 Q16637 1/20 0.62
▸ RXFP1 Q9HBX9 1/20 0.60
▸ CHRNB2 P17787 1/20 0.60
▸ CHRNB4 P30926 1/20 0.60
▸ CHRNA3 P32297 1/20 0.60
▸ CHRNA4 P43681 1/20 0.60
▸ SGMS2 Q8NHU3 1/20 0.57
▸ PKM P14618 1/20 0.54
▸ KCNMA1 Q12791 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25899949 0.84 NPC1 (0.56) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL13162953 0.81 MEN1 (0.69) MEN1KMT2AKDM4EL3MBTL1NPC1
Hydrochloric Acid SCHEMBL30416720 0.79 MEN1 (0.67) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL17675194 0.79 MEN1 (0.71) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL8433498 0.79 MEN1 (1.00) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL9725157 0.78 NPC1 (0.68) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL29444017 0.78 MEN1 (0.69) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL14636633 0.78 MEN1 (0.69) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL30339171 0.78 MEN1 (0.69) MEN1KMT2AKDM4EL3MBTL1NPC1
SCHEMBL19747532 0.78 MEN1 (0.69) MEN1KMT2AKDM4EL3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2879497-B1 METHOD OF COMBATTING SOYBEAN SUDDEN DEATH SYNDROME USING SUBSTITUTED PYRAZOLAMIDES SYNGENTA PARTICIPATIONS AG (CH) 2022-10-05 — — EP disclosed
US-11140903-B2 Fungicidal compositions and methods BAYER CROPSCIENCE LP (US) 2021-10-12 — — US disclosed
EP-3689878-B1 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK-INHIBITORS MERCK SHARP & DOHME (NL) 2021-10-06 — — EP disclosed
US-20210298299-A1 HARMFUL ORGANISM CONTROL COMPOSITION AND METHOD FOR USING THE SAME NIHON NOHYAKU CO., LTD. (JP) 2021-09-30 — — US disclosed
EP-3878282-A1 PEST CONTROL AGENT COMPOSITION AND METHOD FOR USING SAME Nihon Nohyaku Co., Ltd. (JP) 2021-09-15 — — EP disclosed
EP-2630475-B1 DIAGNOSTIC METHOD AND TREATMENT INST SUPERIOR AGRONOMIA (PT) 2020-06-10 — — EP disclosed
US-20200017490-A1 Novel Mesoionic Insecticidal Compound NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2020-01-16 — — US disclosed
EP-3287457-B1 MESOIONIC COMPOUND NIPPON KAYAKU KK (JP) 2019-09-18 — — EP disclosed
US-10390476-B2 Fungicidal compositions and methods BAYER CROPSCIENCE LP (US) 2019-08-27 — — US disclosed
EP-3521287-A1 NOVEL MESOIONIC INSECTICIDAL COMPOUND Nippon Kayaku Kabushiki Kaisha (JP) 2019-08-07 — — EP disclosed
US-20140234438-A1 DIAGNOSTIC METHOD AND TREATMENT INSTITUTO SUPERIOR DE AGRONOMIA (PT) 2014-08-21 — — US disclosed
WO-2014085565-A1 METHODS OF CONTROLLING FUNGAL PATHOGENS USING POLYENE FUNGICIDES BAYER CROPSCIENCE LP (US) 2014-06-05 — — WO disclosed
US-20140148336-A1 METHODS OF CONTROLLING FUNGAL PATHOGENS USING POLYENE FUNGICIDES BAYER CROPSCIENCE LP 2014-05-29 — — US disclosed
WO-2014023627-A1 METHOD OF COMBATTING SUDDEN DEATH SYNDROME IN PLANTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-13 — — WO disclosed
WO-2014023628-A1 METHOD OF COMBATTING SOYBEAN SUDDEN DEATH SYNDROME USING SUBSTITUTED|PYRAZOLAMIDES SYNGENTA PARTICIPATIONS AG (CH) 2014-02-13 — — WO disclosed
US-20130324400-A1 FUNGICIDAL COMPOSITIONS AND METHODS BAYER CROPSCIENCE LP (US) 2013-12-05 — — US disclosed
EP-2642854-A2 FUNGICIDAL COMPOSITIONS AND METHODS Bayer Intellectual Property GmbH (DE) 2013-10-02 — — EP disclosed
EP-2630475-A1 DIAGNOSTIC METHOD AND TREATMENT Instituto Superior de Agronomia (PT) 2013-08-28 — — EP disclosed
WO-2012071520-A2 FUNGICIDAL COMPOSITIONS AND METHODS BAYER CROPSCIENCE LP (US) 2012-05-31 — — WO disclosed
WO-2012052506-A1 DIAGNOSTIC METHOD AND TREATMENT INSTITUTO SUPERIOR DE AGRONOMIA (PT) 2012-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210298299-A1 HARMFUL ORGANISM CONTROL COMPOSITION AND METHOD FOR USING THE SAME C1S, ATL3, C5 MEN1 741/4885KMT2A 2931/4885KDM4E 4739/4885
US-20200017490-A1 Novel Mesoionic Insecticidal Compound DDT, ACHE, ME3 MEN1 310/4885KMT2A 2242/4885KDM4E 1687/4885
US-20130324400-A1 FUNGICIDAL COMPOSITIONS AND METHODS CASP3, CASP9, CASP7 MEN1 1301/4885KMT2A 4225/4885KDM4E 3634/4885
US-10390476-B2 Fungicidal compositions and methods CASP3, CASP9, CASP7 MEN1 1301/4885KMT2A 4225/4885KDM4E 3634/4885
US-11140903-B2 Fungicidal compositions and methods CASP3, CASP9, CASP7 MEN1 1301/4885KMT2A 4225/4885KDM4E 3634/4885
US-20140148336-A1 METHODS OF CONTROLLING FUNGAL PATHOGENS USING POLYENE FUNGICIDES CASP5, CASP10, CASP14 MEN1 1334/4885KMT2A 2805/4885KDM4E 2790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.