Solriamfetol

Solriamfetol

SCHEMBL2739637

NC(=O)OC[C@H](N)Cc1ccccc1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
EPHX1 P07099 2/20 0.55
MMP2 P08253 4/20 0.53
ALPI P09923 1/20 0.52
PTGS1 P23219 1/20 0.52
XIAP P98170 1/20 0.52
SLC7A5 Q01650 1/20 0.52
LMNA P02545 1/20 0.50
SCN4A P35499 2/20 0.49
ANPEP P15144 1/20 0.48
SRR Q9GZT4 2/20 0.47
SLC1A3 P43003 1/20 0.47
SLC1A2 P43004 1/20 0.47
SLC1A1 P43005 1/20 0.47
TACR1 P25103 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Solriamfetol SCHEMBL42526 1.00 PKM (0.56) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL30929348 1.00 PKM (0.56) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL30929349 1.00 PKM (0.56) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL42525 1.00 PKM (0.56) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL8430382 0.98 PKM (0.54) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL28413501 0.98 PKM (0.54) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL4987496 0.98 PKM (0.54) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL8426383 0.98 PKM (0.54) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL30518836 0.97 PKM (0.53) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1
Solriamfetol SCHEMBL30518840 0.95 PKM (0.51) PKMCYP1A2CYP2D6SMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 725 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688731-A1 PROCESS FOR PREPARING (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE INKE, S.A. (ES) 2026-02-11 EP claimed
US-20250367299-A1 GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM ZEVRA THERAPEUTICS INC (US) 2025-12-04 US claimed
US-20250352476-A1 FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE AXSOME MALTA LTD (MT) 2025-11-20 US claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
EP-4633638-A1 TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) Luminous Mind Inc. (US) 2025-10-22 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
US-12390419-B2 Formulations of (R)-2-amino-3-phenylpropyl carbamate AXSOME MALTA LTD. (MT) 2025-08-19 US claimed
US-20250186591-A1 GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM ZEVRA THERAPEUTICS INC (US) 2025-06-12 US claimed
US-20250114322-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-04-10 US claimed
US-12263145-B2 Methods of administering solriamfetol to lactating women AXSOME MALTA LTD. (MT) 2025-04-01 US claimed
CN-102695502-B Compositions for treating drug addiction and improving drug addiction-related behavior SK BIOPHARMACEUTICALS CO LTD 2014-12-24 CN claimed
CN-102781436-B Methods for treating fibromyalgia syndrome SK BIOPHARMACEUTICALS CO LTD 2014-01-08 CN claimed
CN-102762201-B Methods for treating attention-deficit/hyperactivity disorder SK BIOPHARMACEUTICALS CO LTD 2013-12-18 CN claimed
CN-103025326-A Methods of treating restless legs syndrome SK BIOPHARMACEUTICALS CO LTD 2013-04-03 CN claimed
CN-102985085-A Methods for treating bipolar disorder SK BIOPHARMACEUTICALS CO LTD 2013-03-20 CN claimed
CN-102781436-A Methods for treating fibromyalgia syndrome SK HOLDINGS CO LTD 2012-11-14 CN claimed
CN-102762201-A METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER SK HOLDINGS CO LTD 2012-10-31 CN claimed
CN-101217949-B Treating Sleep-Wake Disorders SK CORP 2012-10-17 CN claimed
CN-102695502-A Compositions for treating drug addiction and improving drug addiction-related behavior SK HOLDINGS CO LTD 2012-09-26 CN claimed
CN-101217949-A Treating Sleep-Wake Disorders SK CORP (KR) 2008-07-09 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12390419-B2 Formulations of (R)-2-amino-3-phenylpropyl carbamate PRCP, GRPR, CPS1 PKM 2187/4885CYP1A2 1001/4885CYP2D6 946/4885
US-20250114322-A1 METHODS AND COMPOSITIONS FOR TREATING EXCESSIVE SLEEPINESS CHAT, PNMT, HCRTR1 PKM 1169/4885CYP1A2 1015/4885CYP2D6 2042/4885
US-20250186591-A1 GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM HSD17B10, HSD17B12, HSD17B14 PKM 1909/4885CYP1A2 741/4885CYP2D6 664/4885
US-20250352476-A1 FORMULATIONS OF (R)-2-AMINO-3-PHENYLPROPYL CARBAMATE CPS1, PRCP, GLS2 PKM 1586/4885CYP1A2 527/4885CYP2D6 392/4885
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM S100A8, TP53, AQP1 PKM 3085/4885CYP1A2 4394/4885CYP2D6 4115/4885
US-12263145-B2 Methods of administering solriamfetol to lactating women PGF, OGFRL1, OGFR PKM 1232/4885CYP1A2 1089/4885CYP2D6 199/4885
US-20250367299-A1 GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM HSD17B10, HSD17B12, HSD17B14 PKM 1909/4885CYP1A2 741/4885CYP2D6 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.