Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 16/20 | 0.53 |
| ▸ | MC4R | P32245 | 6/20 | 0.53 |
| ▸ | MC3R | P41968 | 6/20 | 0.53 |
| ▸ | MC1R | Q01726 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368269 | 1.00 | MC5R (0.53) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4050294 | 0.94 | MC5R (0.53) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4050286 | 0.94 | MC5R (0.53) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4050292 | 0.94 | MC5R (0.53) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4045951 | 0.93 | MC5R (0.54) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4045953 | 0.93 | MC5R (0.54) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4045949 | 0.93 | MC5R (0.54) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4038130 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4038136 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RMC1RNAMPT | |
| SCHEMBL4038137 | 0.93 | MC5R (0.52) | MC5RMC4RMC3RMC1RNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |
| US-9133181-B2 | Substituted 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors | SANOFI (FR) | 2015-09-15 | — | — | US | disclosed |
| US-20150133432-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2015-05-14 | — | — | US | disclosed |
| US-8946212-B2 | Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2015-02-03 | — | — | US | disclosed |
| US-8933024-B2 | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases | SANOFI (FR) | 2015-01-13 | — | — | US | disclosed |
| US-8901114-B2 | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof | SANOFI (FR) | 2014-12-02 | — | — | US | disclosed |
| US-8895547-B2 | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof | SANOFI (FR) | 2014-11-25 | — | — | US | disclosed |
| US-8871758-B2 | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof | SANOFI (FR) | 2014-10-28 | — | — | US | disclosed |
| US-8859494-B2 | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament | SANOFI (FR) | 2014-10-14 | — | — | US | disclosed |
| US-8846712-B2 | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors | SANOFI (FR) | 2014-09-30 | — | — | US | disclosed |
| US-20110245263-A1 | 2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | US | disclosed |
| US-20110224263-A1 | Cyclic pyridyl-N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2011-09-15 | — | — | US | disclosed |
| US-20110207738-A1 | ANNELATED PYRROLIDIN SULFONAMIDES WITH OXADIAZOLONE HEADGROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2011-08-25 | — | — | US | disclosed |
| US-20110183998-A1 | HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THE USE THEREOF | SANOFI-AVENTIS (FR) | 2011-07-28 | — | — | US | disclosed |
| US-20110178134-A1 | Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
| US-20110118321-A1 | CARBAMOYLBENZOTRIAZOLE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI-AVENTIS (FR) | 2011-05-19 | — | — | US | disclosed |
| US-20110112097-A1 | Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | SANOFI-AVENTIS (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110059910-A1 | Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds and the use thereof | SANOFI-AVENTIS (FR) | 2011-03-10 | — | — | US | disclosed |
| US-20110053947-A1 | Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | SANOFI-AVENTIS (FR) | 2011-03-03 | — | — | US | disclosed |
| US-20110046185-A1 | Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | SANOFI-AVENTIS (FR) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133432-A1 | SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | MAP3K1, MAP3K6, MAP3K19 | MC5R 1500/4885MC4R 882/4885MC3R 1489/4885 |
| US-20110178134-A1 | Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof | FABP4, GPR119, PGC | MC5R 503/4885MC4R 130/4885MC3R 1553/4885 |
| US-20110046185-A1 | Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | PGC, LIPC, CEL | MC5R 302/4885MC4R 150/4885MC3R 541/4885 |
| US-20110183998-A1 | HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THE USE THEREOF | CS, CYP11B1, GPR119 | MC5R 133/4885MC4R 92/4885MC3R 148/4885 |
| US-20110245263-A1 | 2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD | SCD, SCD5, PYCR1 | MC5R 2187/4885MC4R 2613/4885MC3R 1558/4885 |
| US-20110118321-A1 | CARBAMOYLBENZOTRIAZOLE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | PNLIP, PLAAT2, CEL | MC5R 4467/4885MC4R 4517/4885MC3R 4739/4885 |
| US-20110059910-A1 | Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds and the use thereof | SLC5A2, SLC5A1, SLC2A2 | MC5R 1050/4885MC4R 443/4885MC3R 1163/4885 |
| US-20110207738-A1 | ANNELATED PYRROLIDIN SULFONAMIDES WITH OXADIAZOLONE HEADGROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | PPARD, PPARA, PPARG | MC5R 2305/4885MC4R 772/4885MC3R 1473/4885 |
| US-20110053947-A1 | Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | PGC, LIPC, CEL | MC5R 422/4885MC4R 235/4885MC3R 730/4885 |
| US-20110224263-A1 | Cyclic pyridyl-N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals | PPARD, PPARG, PPARA | MC5R 1929/4885MC4R 1393/4885MC3R 1786/4885 |
| US-20110112097-A1 | Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof | GIPR, PGC, DDC | MC5R 221/4885MC4R 120/4885MC3R 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.