Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 2/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.67 |
| ▸ | FPR2 | P25090 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746998 | 1.00 | GAPDH (0.67) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| SCHEMBL1781902 | 0.83 | GAPDH (0.65) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| SCHEMBL1781901 | 0.83 | GAPDH (0.65) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| 4-Hydroxynon-2-Enal SCHEMBL3921 | 0.80 | GAPDH (1.00) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| 4-Hydroxynon-2-Enal SCHEMBL2890601 | 0.80 | GAPDH (1.00) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| 4-Hydroxynon-2-Enal SCHEMBL3920 | 0.80 | GAPDH (1.00) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| 4-Hydroxynon-2-Enal SCHEMBL2890600 | 0.80 | GAPDH (1.00) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| 4-Hydroxynon-2-Enal SCHEMBL30767210 | 0.80 | GAPDH (1.00) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| SCHEMBL13703885 | 0.79 | FPR2 (0.60) | GAPDHTRPA1MAPTDDAH1FPR2 | |
| SCHEMBL9301586 | 0.79 | FPR2 (0.83) | FPR2NFKB1NFKB2RELAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178516-B2 | Composition of 4-guanidinobenzoic acid HCl, a co-agent suitable for systemic administration solely via the oral route, antioxidants, vitamins, metabolites | Sylvan Labs, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20080234380-A1 | Compositions and method for treatment of chronic inflammatory diseases | SHAPIRO HOWARD K | 2008-09-25 | — | — | US | disclosed |
| US-20050090553-A1 | Compositions and method for treatment of chronic inflammatory diseases | SECANT PHARMA, LLC | 2005-04-28 | — | — | US | disclosed |
| US-6444221-B1 | ADMINISTERING AMINOBENZOIC ACID | SECANT PHARMA, LLC | 2002-09-03 | — | — | US | disclosed |
| EP-0604641-B1 | USE OF A COMBINATION CONTAINING AN AMINE OR AMINE-RELATED DERIVATIVE OF BENZOIC ACID AND AN AMINO-POLYSACCHARIDE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-1994000135-A1 | COMPOSITION CONTAINING AMINE AND AMINE-RELATED DERIVATIVES OF BENZOIC ACID AND USES THEREFOR INCLUDING TREATING INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1994-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090553-A1 | Compositions and method for treatment of chronic inflammatory diseases | PCCA, HMGB1, PTGES | GAPDH 304/4885TRPA1 441/4885MAPT 2712/4885 |
| US-20080234380-A1 | Compositions and method for treatment of chronic inflammatory diseases | HMGB1, PCCA, QSOX1 | GAPDH 341/4885TRPA1 589/4885MAPT 3087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.