Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Gtp. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 known ✓ | P41231 | 3/20 | 0.67 |
| ▸ | P2RY4 known ✓ | P51582 | 1/20 | 0.67 |
| ▸ | P2RY6 known ✓ | Q15077 | 1/20 | 0.67 |
| ▸ | P2RY1 known ✓ | P47900 | 3/20 | 0.62 |
| ▸ | TGM2 | P21980 | 1/20 | 0.79 |
| ▸ | NT5E | P21589 | 1/20 | 0.74 |
| ▸ | KRAS | P01116 | 5/20 | 0.74 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.73 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.69 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.62 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.62 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067722 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL851357 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL29429843 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL18769114 | 0.96 | TGM2 (0.85) | TGM2NT5EKRASFUT5P2RX3 | |
| Gtp SCHEMBL18271799 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL376140 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| Gtp SCHEMBL18784960 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL2593095 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| SCHEMBL19691775 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 | |
| Gtp SCHEMBL96708 | 0.93 | TGM2 (0.81) | TGM2NT5EKRASFUT5P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103344764-B | Reagent, method and kit for detection of biological activity of glucagon-like peptide-1 (GLP-1) | TIANJIN MD PACIFIC TECHNOLOGY CO LTD | 2014-11-26 | — | — | CN | disclosed |
| CN-103344764-A | Reagent, method and kit for detection of biological activity of glucagon-like peptide-1 (GLP-1) | TIANJIN MD PACIFIC TECHNOLOGY CO LTD | 2013-10-09 | — | — | CN | disclosed |