Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822397 | 0.86 | PTPN1 (0.55) | HTTSMN1; SMN2EPHX2PTPN2PTPN1 | |
| SCHEMBL28033000 | 0.86 | L3MBTL1 (0.60) | SMN1; SMN2EPHX2PTPN2PTPN1PTPN6 | |
| SCHEMBL28092176 | 0.86 | GLA (0.58) | ACHEBACE1SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL28264102 | 0.83 | PTPN1 (0.52) | HTTSMN1; SMN2NPSR1ALDH1A1PTPN2 | |
| SCHEMBL2710950 | 0.82 | PTPN2 (0.79) | HTTACHEBACE1SMN1; SMN2HPGD | |
| SCHEMBL28033057 | 0.82 | ACHE (0.53) | ACHEBACE1SMN1; SMN2ALDH1A1PTPN2 | |
| SCHEMBL28032935 | 0.81 | MAPT (0.72) | SMN1; SMN2ALDH1A1MAPTLMNAHSD17B10 | |
| SCHEMBL8324607 | 0.81 | MTNR1A (0.71) | HTTACHEBACE1SMN1; SMN2HPGD | |
| SCHEMBL5205624 | 0.78 | NPC1 (0.69) | HTTACHEBACE1HPGDEPHX2 | |
| SCHEMBL3188745 | 0.77 | ENPP3 (0.69) | HTTHPGDEPHX2PTPN1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104945470-A | Tripeptide epoxy ketone compound constructed by heterocycle as well as preparation method and application thereof | UNIV ZHEJIANG | 2015-09-30 | — | — | CN | disclosed |